Kii I - Search Results

1

Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.

Kurihara T, Sakurai E, Toyomoto M, Kii I, Kawamoto D, Asada T, Tanabe T, Yoshimura M, Hagiwara M, Miyata A. Kurihara T, et al. Among authors: kii i. Mol Pain. 2014 Mar 10;10:17. doi: 10.1186/1744-8069-10-17. Mol Pain. 2014. PMID: 24612480 Free PMC article.

2

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.

Morooka S, Hoshina M, Kii I, Okabe T, Kojima H, Inoue N, Okuno Y, Denawa M, Yoshida S, Fukuhara J, Ninomiya K, Ikura T, Furuya T, Nagano T, Noda K, Ishida S, Hosoya T, Ito N, Yoshimura N, Hagiwara M. Morooka S, et al. Among authors: kii i. Mol Pharmacol. 2015 Aug;88(2):316-25. doi: 10.1124/mol.114.097345. Epub 2015 May 20. Mol Pharmacol. 2015. PMID: 25993998

3

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy.

Sako Y, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, Koike Y, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, Hagiwara M. Sako Y, et al. Among authors: kii i. Sci Rep. 2017 May 30;7:46126. doi: 10.1038/srep46126. Sci Rep. 2017. PMID: 28555643 Free PMC article.

4

S1PR3-G₁₂-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.

Toyomoto M, Inoue A, Iida K, Denawa M, Kii I, Ngako Kadji FM, Kishi T, Im D, Shimamura T, Onogi H, Yoshida S, Iwata S, Aoki J, Hosoya T, Hagiwara M. Toyomoto M, et al. Among authors: kii i. Cell Chem Biol. 2021 Aug 19;28(8):1132-1144.e9. doi: 10.1016/j.chembiol.2021.01.004. Epub 2021 Feb 8. Cell Chem Biol. 2021. PMID: 33561428 Free article.

5

Selective inhibition of the kinase DYRK1A by targeting its folding process.

Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, Hagiwara M. Kii I, et al. Nat Commun. 2016 Apr 22;7:11391. doi: 10.1038/ncomms11391. Nat Commun. 2016. PMID: 27102360 Free PMC article.

6

Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.

Masaki S, Kii I, Sumida Y, Kato-Sumida T, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N, Hosoya T, Hagiwara M. Masaki S, et al. Among authors: kii i. Bioorg Med Chem. 2015 Aug 1;23(15):4434-4441. doi: 10.1016/j.bmc.2015.06.018. Epub 2015 Jun 14. Bioorg Med Chem. 2015. PMID: 26145823

7

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.

Sonamoto R, Kii I, Koike Y, Sumida Y, Kato-Sumida T, Okuno Y, Hosoya T, Hagiwara M. Sonamoto R, et al. Among authors: kii i. Sci Rep. 2015 Aug 3;5:12728. doi: 10.1038/srep12728. Sci Rep. 2015. PMID: 26234946 Free PMC article.

8

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice.

Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M. Nakano-Kobayashi A, et al. Among authors: kii i. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10268-10273. doi: 10.1073/pnas.1704143114. Epub 2017 Sep 5. Proc Natl Acad Sci U S A. 2017. PMID: 28874550 Free PMC article.

9

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.

Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M. Ogawa Y, et al. Among authors: kii i. Nat Commun. 2010 Oct 5;1:86. doi: 10.1038/ncomms1090. Nat Commun. 2010. PMID: 20981014 Free article.

10

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions.

Yoshida S , Kanno K , Kii I , Misawa Y , Hagiwara M , Hosoya T . Yoshida S , et al. Among authors: kii i. Chem Commun (Camb). 2018 Apr 10;54(30):3705-3708. doi: 10.1039/c8cc01195h. Chem Commun (Camb). 2018. PMID: 29527608

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