Thein SL - Search Results

1

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers.

Stadhouders R, Aktuna S, Thongjuea S, Aghajanirefah A, Pourfarzad F, van Ijcken W, Lenhard B, Rooks H, Best S, Menzel S, Grosveld F, Thein SL, Soler E. Stadhouders R, et al. Among authors: thein sl. J Clin Invest. 2014 Apr;124(4):1699-710. doi: 10.1172/JCI71520. Epub 2014 Mar 10. J Clin Invest. 2014. PMID: 24614105 Free PMC article.

2

The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells.

Wahlberg K, Jiang J, Rooks H, Jawaid K, Matsuda F, Yamaguchi M, Lathrop M, Thein SL, Best S. Wahlberg K, et al. Among authors: thein sl. Blood. 2009 Aug 6;114(6):1254-62. doi: 10.1182/blood-2009-03-210146. Epub 2009 Jun 15. Blood. 2009. PMID: 19528534 Free article.

3

cMYB is involved in the regulation of fetal hemoglobin production in adults.

Jiang J, Best S, Menzel S, Silver N, Lai MI, Surdulescu GL, Spector TD, Thein SL. Jiang J, et al. Among authors: thein sl. Blood. 2006 Aug 1;108(3):1077-83. doi: 10.1182/blood-2006-01-008912. Blood. 2006. PMID: 16861354 Free article.

4

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.

Thein SL, Menzel S, Peng X, Best S, Jiang J, Close J, Silver N, Gerovasilli A, Ping C, Yamaguchi M, Wahlberg K, Ulug P, Spector TD, Garner C, Matsuda F, Farrall M, Lathrop M. Thein SL, et al. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11346-51. doi: 10.1073/pnas.0611393104. Epub 2007 Jun 25. Proc Natl Acad Sci U S A. 2007. PMID: 17592125 Free PMC article.

5

HbA2 levels in normal adults are influenced by two distinct genetic mechanisms.

Menzel S, Garner C, Rooks H, Spector TD, Thein SL. Menzel S, et al. Among authors: thein sl. Br J Haematol. 2013 Jan;160(1):101-5. doi: 10.1111/bjh.12084. Epub 2012 Oct 9. Br J Haematol. 2013. PMID: 23043469 Free article.

6

Genetic Modifiers of Fetal Haemoglobin in Sickle Cell Disease.

Menzel S, Thein SL. Menzel S, et al. Among authors: thein sl. Mol Diagn Ther. 2019 Apr;23(2):235-244. doi: 10.1007/s40291-018-0370-8. Mol Diagn Ther. 2019. PMID: 30478714 Review.

7

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer.

Mtatiro SN, Mgaya J, Singh T, Mariki H, Rooks H, Soka D, Mmbando B, Thein SL, Barrett JC, Makani J, Cox SE, Menzel S. Mtatiro SN, et al. Among authors: thein sl. BMC Med Genet. 2015 Feb 10;16:4. doi: 10.1186/s12881-015-0148-3. BMC Med Genet. 2015. PMID: 25928412 Free PMC article.

8

The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.

Menzel S, Jiang J, Silver N, Gallagher J, Cunningham J, Surdulescu G, Lathrop M, Farrall M, Spector TD, Thein SL. Menzel S, et al. Among authors: thein sl. Blood. 2007 Nov 15;110(10):3624-6. doi: 10.1182/blood-2007-05-093419. Epub 2007 Aug 21. Blood. 2007. PMID: 17712044 Free article.

9

Discovering the genetics underlying foetal haemoglobin production in adults.

Thein SL, Menzel S. Thein SL, et al. Br J Haematol. 2009 May;145(4):455-67. doi: 10.1111/j.1365-2141.2009.07650.x. Epub 2008 Mar 2. Br J Haematol. 2009. PMID: 19344402 Free article. Review.

10

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.

Thein SL, Menzel S, Lathrop M, Garner C. Thein SL, et al. Hum Mol Genet. 2009 Oct 15;18(R2):R216-23. doi: 10.1093/hmg/ddp401. Hum Mol Genet. 2009. PMID: 19808799 Free PMC article. Review.

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