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Purine analog-like properties of bendamustine underlie rapid activation of DNA damage response and synergistic effects with pyrimidine analogues in lymphoid malignancies.
Hiraoka N, Kikuchi J, Yamauchi T, Koyama D, Wada T, Uesawa M, Akutsu M, Mori S, Nakamura Y, Ueda T, Kano Y, Furukawa Y. Hiraoka N, et al. Among authors: wada t. PLoS One. 2014 Mar 13;9(3):e90675. doi: 10.1371/journal.pone.0090675. eCollection 2014. PLoS One. 2014. PMID: 24626203 Free PMC article.
The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases.
Kikuchi J, Yamada S, Koyama D, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Furukawa Y. Kikuchi J, et al. Among authors: wada t. J Biol Chem. 2013 Aug 30;288(35):25593-25602. doi: 10.1074/jbc.M113.480574. Epub 2013 Jul 22. J Biol Chem. 2013. PMID: 23878197 Free PMC article. Clinical Trial.
4,576 results