Birsoy K - Search Results

1

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. Grabiner BC, et al. Among authors: birsoy k. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. Cancer Discov. 2014. PMID: 24631838 Free PMC article.

2

Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals.

Kenny TC, Khan A, Son Y, Yue L, Heissel S, Sharma A, Pasolli HA, Liu Y, Gamazon ER, Alwaseem H, Hite RK, Birsoy K. Kenny TC, et al. Among authors: birsoy k. Cell Metab. 2023 Jun 6;35(6):1057-1071.e12. doi: 10.1016/j.cmet.2023.04.003. Epub 2023 Apr 25. Cell Metab. 2023. PMID: 37100056 Free PMC article.

3

Spotlight on GOT2 in Cancer Metabolism.

Kerk SA, Garcia-Bermudez J, Birsoy K, Sherman MH, Shah YM, Lyssiotis CA. Kerk SA, et al. Among authors: birsoy k. Onco Targets Ther. 2023 Aug 22;16:695-702. doi: 10.2147/OTT.S382161. eCollection 2023. Onco Targets Ther. 2023. PMID: 37635751 Free PMC article. Review.

4

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Possemato R, et al. Among authors: birsoy k. Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350. Nature. 2011. PMID: 21760589 Free PMC article.

5

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM. Yilmaz ÖH, et al. Among authors: birsoy k. Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163. Nature. 2012. PMID: 22722868 Free PMC article.

6

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.

Birsoy K, Sabatini DM, Possemato R. Birsoy K, et al. Nat Med. 2012 Jul 6;18(7):1022-3. doi: 10.1038/nm.2870. Nat Med. 2012. PMID: 22772555 No abstract available.

7

DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM. Laplante M, et al. Among authors: birsoy k. Cell Metab. 2012 Aug 8;16(2):202-12. doi: 10.1016/j.cmet.2012.07.008. Cell Metab. 2012. PMID: 22883231 Free PMC article.

8

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM. Birsoy K, et al. Nat Genet. 2013 Jan;45(1):104-8. doi: 10.1038/ng.2471. Epub 2012 Dec 2. Nat Genet. 2013. PMID: 23202129 Free PMC article.

9

The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.

Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. Soliman MA, et al. Among authors: birsoy k. Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Sci Signal. 2014. PMID: 24550542 Free PMC article.

10

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM. Birsoy K, et al. Nature. 2014 Apr 3;508(7494):108-12. doi: 10.1038/nature13110. Epub 2014 Mar 16. Nature. 2014. PMID: 24670634 Free PMC article.

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