Geys HM - Search Results

1

Abuse liability assessment in preclinical drug development: predictivity of a translational approach for abuse liability testing using methylphenidate in four standardized preclinical study models.

Teuns GB, Geys HM, Geuens SM, Stinissen P, Meert TF. Teuns GB, et al. Among authors: geys hm. J Pharmacol Toxicol Methods. 2014 Nov-Dec;70(3):295-309. doi: 10.1016/j.vascn.2014.02.002. Epub 2014 Mar 12. J Pharmacol Toxicol Methods. 2014. PMID: 24632211

2

A high-dimensional joint model for longitudinal outcomes of different nature.

Faes C, Aerts M, Molenberghs G, Geys H, Teuns G, Bijnens L. Faes C, et al. Stat Med. 2008 Sep 30;27(22):4408-27. doi: 10.1002/sim.3314. Stat Med. 2008. PMID: 18551509

3

Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats.

Torremans A, Ahnaou A, Van Hemelrijck A, Straetemans R, Geys H, Vanhoof G, Meert TF, Drinkenburg WH. Torremans A, et al. Acta Neurobiol Exp (Wars). 2010;70(1):13-9. doi: 10.55782/ane-2010-1769. Acta Neurobiol Exp (Wars). 2010. PMID: 20407482 Free article.

4

On the use of historical control data in pre-clinical safety studies.

Marringwa JT, Faes C, Aerts M, Geys H, Teuns G, Van Den Poel B, Bijnens L. Marringwa JT, et al. J Biopharm Stat. 2007;17(3):493-509. doi: 10.1080/10543400701216355. J Biopharm Stat. 2007. PMID: 17479396

5

A translational assessment of preclinical versus clinical tools for the measurement of cardiac contractility: comparison of LV dP/dt(max) with echocardiography in telemetry implanted beagle dogs.

Cools F, Dhuyvetter D, Vanlommel A, Janssens S, Borghys H, Geys H, Gallacher DJ. Cools F, et al. J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):17-23. doi: 10.1016/j.vascn.2013.10.003. Epub 2013 Oct 16. J Pharmacol Toxicol Methods. 2014. PMID: 24140387

6

Evaluation of p-phenylenediamine, o-phenylphenol sodium salt, and 2,4-diaminotoluene in the rat comet assay as part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay.

De Boeck M, van der Leede BJ, De Vlieger K, Geys H, Vynckier A, Van Gompel J. De Boeck M, et al. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:151-7. doi: 10.1016/j.mrgentox.2015.04.002. Epub 2015 Apr 7. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 26212306

7

The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative.

Ewart L, Aylott M, Deurinck M, Engwall M, Gallacher DJ, Geys H, Jarvis P, Ju H, Leishman D, Leong L, McMahon N, Mead A, Milliken P, Suter W, Teisman A, Van Ammel K, Vargas HM, Wallis R, Valentin JP. Ewart L, et al. Among authors: geys h. Toxicol Sci. 2014 Dec;142(2):427-35. doi: 10.1093/toxsci/kfu198. Epub 2014 Sep 21. Toxicol Sci. 2014. PMID: 25246669

8

Carcinogenicity in rats of the SGLT2 inhibitor canagliflozin.

De Jonghe S, Proctor J, Vinken P, Feyen B, Wynant I, Marien D, Geys H, Mamidi RN, Johnson MD. De Jonghe S, et al. Chem Biol Interact. 2014 Dec 5;224:1-12. doi: 10.1016/j.cbi.2014.09.018. Epub 2014 Oct 5. Chem Biol Interact. 2014. PMID: 25289773

9

Testing of acetaminophen in support of the international multilaboratory in vivo rat Pig-a assay validation trial.

van der Leede BJ, Weiner S, Van Doninck T, De Vlieger K, Schuermans A, Tekle F, Geys H, van Heerden M, De Jonghe S, Van Gompel J. van der Leede BJ, et al. Environ Mol Mutagen. 2020 Jun;61(5):508-525. doi: 10.1002/em.22368. Epub 2020 Apr 15. Environ Mol Mutagen. 2020. PMID: 32187737 Free PMC article.

10

A Bayesian K-PD model for synergy: A case study.

La Gamba F, Jacobs T, Geys H, Ver Donck L, Faes C. La Gamba F, et al. Pharm Stat. 2018 Nov;17(6):674-684. doi: 10.1002/pst.1887. Epub 2018 Jul 19. Pharm Stat. 2018. PMID: 30027596

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