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45 results

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Page 1
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.
Lee EC, Liang Q, Ali H, Bayliss L, Beasley A, Bloomfield-Gerdes T, Bonoli L, Brown R, Campbell J, Carpenter A, Chalk S, Davis A, England N, Fane-Dremucheva A, Franz B, Germaschewski V, Holmes H, Holmes S, Kirby I, Kosmac M, Legent A, Lui H, Manin A, O'Leary S, Paterson J, Sciarrillo R, Speak A, Spensberger D, Tuffery L, Waddell N, Wang W, Wells S, Wong V, Wood A, Owen MJ, Friedrich GA, Bradley A. Lee EC, et al. Among authors: manin a. Nat Biotechnol. 2014 Apr;32(4):356-63. doi: 10.1038/nbt.2825. Epub 2014 Mar 16. Nat Biotechnol. 2014. PMID: 24633243
Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates.
Pabst M, McDowell W, Manin A, Kyle A, Camper N, De Juan E, Parekh V, Rudge F, Makwana H, Kantner T, Parekh H, Michelet A, Sheng X, Popa G, Tucker C, Khayrzad F, Pollard D, Kozakowska K, Resende R, Jenkins A, Simoes F, Morris D, Williams P, Badescu G, Baker MP, Bird M, Frigerio M, Godwin A. Pabst M, et al. Among authors: manin a. J Control Release. 2017 May 10;253:160-164. doi: 10.1016/j.jconrel.2017.02.027. Epub 2017 Mar 1. J Control Release. 2017. PMID: 28257988
In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab-MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios.
Bryant P, Pabst M, Badescu G, Bird M, McDowell W, Jamieson E, Swierkosz J, Jurlewicz K, Tommasi R, Henseleit K, Sheng X, Camper N, Manin A, Kozakowska K, Peciak K, Laurine E, Grygorash R, Kyle A, Morris D, Parekh V, Abhilash A, Choi JW, Edwards J, Frigerio M, Baker MP, Godwin A. Bryant P, et al. Among authors: manin a. Mol Pharm. 2015 Jun 1;12(6):1872-9. doi: 10.1021/acs.molpharmaceut.5b00116. Epub 2015 May 5. Mol Pharm. 2015. PMID: 25894424
Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance.
Evans N, Grygorash R, Williams P, Kyle A, Kantner T, Pathak R, Sheng X, Simoes F, Makwana H, Resende R, de Juan E, Jenkins A, Morris D, Michelet A, Jewitt F, Rudge F, Camper N, Manin A, McDowell W, Pabst M, Godwin A, Frigerio M, Bird M. Evans N, et al. Among authors: manin a. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022. Front Pharmacol. 2022. PMID: 35784686 Free PMC article.
The genomic natural history of the aurochs.
Rossi C, Sinding MS, Mullin VE, Scheu A, Erven JAM, Verdugo MP, Daly KG, Ciucani MM, Mattiangeli V, Teasdale MD, Diquelou D, Manin A, Bangsgaard P, Collins M, Lord TC, Zeibert V, Zorzin R, Vinter M, Timmons Z, Kitchener AC, Street M, Haruda AF, Tabbada K, Larson G, Frantz LAF, Gehlen B, Alhaique F, Tagliacozzo A, Fornasiero M, Pandolfi L, Karastoyanova N, Sørensen L, Kiryushin K, Ekström J, Mostadius M, Grandal-d'Anglade A, Vidal-Gorosquieta A, Benecke N, Kropp C, Grushin SP, Gilbert MTP, Merts I, Merts V, Outram AK, Rosengren E, Kosintsev P, Sablin M, Tishkin AA, Makarewicz CA, Burger J, Bradley DG. Rossi C, et al. Among authors: manin a. Nature. 2024 Nov;635(8037):136-141. doi: 10.1038/s41586-024-08112-6. Epub 2024 Oct 30. Nature. 2024. PMID: 39478219
45 results