Roberts RA - Search Results

1

An integrated characterization of serological, pathological, and functional events in doxorubicin-induced cardiotoxicity.

Cove-Smith L, Woodhouse N, Hargreaves A, Kirk J, Smith S, Price SA, Galvin M, Betts CJ, Brocklehurst S, Backen A, Radford J, Linton K, Roberts RA, Schmitt M, Dive C, Tugwood JD, Hockings PD, Mellor HR. Cove-Smith L, et al. Among authors: roberts ra. Toxicol Sci. 2014 Jul;140(1):3-15. doi: 10.1093/toxsci/kfu057. Epub 2014 Mar 27. Toxicol Sci. 2014. PMID: 24675088

2

Reducing attrition in drug development: smart loading preclinical safety assessment.

Roberts RA, Kavanagh SL, Mellor HR, Pollard CE, Robinson S, Platz SJ. Roberts RA, et al. Drug Discov Today. 2014 Mar;19(3):341-7. doi: 10.1016/j.drudis.2013.11.014. Epub 2013 Nov 21. Drug Discov Today. 2014. PMID: 24269835 Review.

3

A peroxisome proliferator-activated receptor-alpha (PPARalpha) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARalpha: implications for species differences in responses to peroxisome proliferators.

Tugwood JD, Holden PR, James NH, Prince RA, Roberts RA. Tugwood JD, et al. Among authors: roberts ra. Arch Toxicol. 1998 Feb;72(3):169-77. doi: 10.1007/s002040050483. Arch Toxicol. 1998. PMID: 9520140

4

Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis.

James NH, Gill JH, Brindle R, Woodyatt NJ, Macdonald N, Rolfe M, Hasmall SC, Tugwood JD, Holden PR, Roberts RA. James NH, et al. Among authors: roberts ra. Toxicol Lett. 1998 Dec 28;102-103:91-6. doi: 10.1016/s0378-4274(98)00291-4. Toxicol Lett. 1998. PMID: 10022238 Review.

5

Inducible EGFR T790M-mediated gefitinib resistance in non-small cell lung cancer cells does not modulate sensitivity to PI103 provoked autophagy.

Moreira-Leite FF, Harrison LR, Mironov A, Roberts RA, Dive C. Moreira-Leite FF, et al. Among authors: roberts ra. J Thorac Oncol. 2010 Jun;5(6):765-77. doi: 10.1097/JTO.0b013e3181d95d93. J Thorac Oncol. 2010. PMID: 20421816 Free article.

6

The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.

Gill JH, James NH, Roberts RA, Dive C. Gill JH, et al. Among authors: roberts ra. Carcinogenesis. 1998 Feb;19(2):299-304. doi: 10.1093/carcin/19.2.299. Carcinogenesis. 1998. PMID: 9498280

7

The rodent non-genotoxic hepatocarcinogen nafenopin suppresses apoptosis preferentially in non-cycling hepatocytes but also elevates CDK4, a cell cycle progression factor.

Gill JH, Brickell P, Dive C, Roberts RA. Gill JH, et al. Among authors: roberts ra. Carcinogenesis. 1998 Oct;19(10):1743-7. doi: 10.1093/carcin/19.10.1743. Carcinogenesis. 1998. PMID: 9806153

8

Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha).

Roberts RA, James NH, Woodyatt NJ, Macdonald N, Tugwood JD. Roberts RA, et al. Carcinogenesis. 1998 Jan;19(1):43-8. doi: 10.1093/carcin/19.1.43. Carcinogenesis. 1998. PMID: 9472691

9

The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs.

Woodyatt NJ, Lambe KG, Myers KA, Tugwood JD, Roberts RA. Woodyatt NJ, et al. Among authors: roberts ra. Carcinogenesis. 1999 Mar;20(3):369-72. doi: 10.1093/carcin/20.3.369. Carcinogenesis. 1999. PMID: 10190548

10

Non-genotoxic hepatocarcinogenesis in vitro: the FaO hepatoma line responds to peroxisome proliferators and retains the ability to undergo apoptosis.

Bayly AC, French NJ, Dive C, Roberts RA. Bayly AC, et al. Among authors: roberts ra. J Cell Sci. 1993 Feb;104 ( Pt 2):307-15. doi: 10.1242/jcs.104.2.307. J Cell Sci. 1993. PMID: 8389374

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