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Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota.
Piazzi G, D'Argenio G, Prossomariti A, Lembo V, Mazzone G, Candela M, Biagi E, Brigidi P, Vitaglione P, Fogliano V, D'Angelo L, Fazio C, Munarini A, Belluzzi A, Ceccarelli C, Chieco P, Balbi T, Loadman PM, Hull MA, Romano M, Bazzoli F, Ricciardiello L. Piazzi G, et al. Int J Cancer. 2014 Nov 1;135(9):2004-13. doi: 10.1002/ijc.28853. Epub 2014 Mar 28. Int J Cancer. 2014. PMID: 24676631
A combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cells.
D'Angelo L, Piazzi G, Pacilli A, Prossomariti A, Fazio C, Montanaro L, Graziani G, Fogliano V, Munarini A, Bianchi F, Belluzzi A, Bazzoli F, Ricciardiello L. D'Angelo L, et al. Among authors: piazzi g. Carcinogenesis. 2014 Oct;35(10):2314-20. doi: 10.1093/carcin/bgu173. Epub 2014 Aug 14. Carcinogenesis. 2014. PMID: 25123131
Short-term treatment with eicosapentaenoic acid improves inflammation and affects colonic differentiation markers and microbiota in patients with ulcerative colitis.
Prossomariti A, Scaioli E, Piazzi G, Fazio C, Bellanova M, Biagi E, Candela M, Brigidi P, Consolandi C, Balbi T, Chieco P, Munarini A, Pariali M, Minguzzi M, Bazzoli F, Belluzzi A, Ricciardiello L. Prossomariti A, et al. Among authors: piazzi g. Sci Rep. 2017 Aug 7;7(1):7458. doi: 10.1038/s41598-017-07992-1. Sci Rep. 2017. PMID: 28785079 Free PMC article.
A Mediterranean Diet Mix Has Chemopreventive Effects in a Murine Model of Colorectal Cancer Modulating Apoptosis and the Gut Microbiota.
Piazzi G, Prossomariti A, Baldassarre M, Montagna C, Vitaglione P, Fogliano V, Biagi E, Candela M, Brigidi P, Balbi T, Munarini A, Belluzzi A, Pariali M, Bazzoli F, Ricciardiello L. Piazzi G, et al. Front Oncol. 2019 Mar 12;9:140. doi: 10.3389/fonc.2019.00140. eCollection 2019. Front Oncol. 2019. PMID: 30915275 Free PMC article.
Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?
Prossomariti A, Piazzi G, Alquati C, Ricciardiello L. Prossomariti A, et al. Among authors: piazzi g. Cell Mol Gastroenterol Hepatol. 2020;10(3):491-506. doi: 10.1016/j.jcmgh.2020.04.007. Epub 2020 Apr 22. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32334125 Free PMC article. Review.
Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) mice.
Fini L, Piazzi G, Ceccarelli C, Daoud Y, Belluzzi A, Munarini A, Graziani G, Fogliano V, Selgrad M, Garcia M, Gasbarrini A, Genta RM, Boland CR, Ricciardiello L. Fini L, et al. Among authors: piazzi g. Clin Cancer Res. 2010 Dec 1;16(23):5703-11. doi: 10.1158/1078-0432.CCR-10-1990. Epub 2010 Oct 28. Clin Cancer Res. 2010. PMID: 21030497 Free PMC article.
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