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Implications of retinal effects observed in chronic toxicity studies on the clinical development of a CNS-active drug candidate.
Eichenbaum G, Zhou J, Kelley MF, Roosen W, Costa-Giomi P, Louden C, Di Prospero NA, Pandina G, Singh JB, Ford L, Moyer JA, Nork TM, Ver Hoeve JN, Aguirre GD. Eichenbaum G, et al. Among authors: louden c. Regul Toxicol Pharmacol. 2014 Jul;69(2):187-200. doi: 10.1016/j.yrtph.2014.03.005. Epub 2014 Mar 26. Regul Toxicol Pharmacol. 2014. PMID: 24680767
Nonclinical safety assessment of a synthetic peptide thrombopoietin agonist: effects on platelets, bone homeostasis, and immunogenicity and the implications for clinical safety monitoring of adverse bone effects.
Knight E, Eichenbaum G, Hillsamer V, Greway T, Tonelli A, Han-Hsu H, Zakszewski C, Yurkow E, Shukla U, End D, Louden C. Knight E, et al. Among authors: louden c. Int J Toxicol. 2011 Aug;30(4):385-404. doi: 10.1177/1091581811404708. Int J Toxicol. 2011. PMID: 21832269
Scientific and Regulatory Policy Committee Points-to-consider Paper*: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part 2. Antisense Oligonucleotides.
Engelhardt JA, Fant P, Guionaud S, Henry SP, Leach MW, Louden C, Scicchitano MS, Weaver JL, Zabka TS, Frazier KS; Society of Toxicologic Pathology Vascular Injury Working Group. Engelhardt JA, et al. Among authors: louden c. Toxicol Pathol. 2015 Oct;43(7):935-44. doi: 10.1177/0192623315570341. Epub 2015 Feb 24. Toxicol Pathol. 2015. PMID: 25717082 Review.
74 results