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ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents.
McGuigan C, Derudas M, Gonczy B, Hinsinger K, Kandil S, Pertusati F, Serpi M, Snoeck R, Andrei G, Balzarini J, McHugh TD, Maitra A, Akorli E, Evangelopoulos D, Bhakta S. McGuigan C, et al. Among authors: evangelopoulos d. Bioorg Med Chem. 2014 May 1;22(9):2816-24. doi: 10.1016/j.bmc.2014.02.056. Epub 2014 Mar 15. Bioorg Med Chem. 2014. PMID: 24690527 Free article.
Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria.
Bhakta S, Scalacci N, Maitra A, Brown AK, Dasugari S, Evangelopoulos D, McHugh TD, Mortazavi PN, Twist A, Petricci E, Manetti F, Castagnolo D. Bhakta S, et al. Among authors: evangelopoulos d. J Med Chem. 2016 Mar 24;59(6):2780-93. doi: 10.1021/acs.jmedchem.6b00031. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26907951 Free article.
Improving the tuberculosis drug development pipeline.
Evangelopoulos D, McHugh TD. Evangelopoulos D, et al. Chem Biol Drug Des. 2015 Nov;86(5):951-60. doi: 10.1111/cbdd.12549. Epub 2015 Mar 28. Chem Biol Drug Des. 2015. PMID: 25772393 Review.
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E. Ryan A, et al. Among authors: evangelopoulos d. Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9. Br J Pharmacol. 2017. PMID: 28380256 Free PMC article.
159 results