Kumar S - Search Results

1

Application of chimeric mice with humanized liver for study of human-specific drug metabolism.

Bateman TJ, Reddy VG, Kakuni M, Morikawa Y, Kumar S. Bateman TJ, et al. Among authors: kumar s. Drug Metab Dispos. 2014 Jun;42(6):1055-65. doi: 10.1124/dmd.114.056978. Epub 2014 Apr 3. Drug Metab Dispos. 2014. PMID: 24700822

2

Lymphatic absorption, metabolism, and excretion of a therapeutic peptide in dogs and rats.

Zou Y, Bateman TJ, Adreani C, Shen X, Cunningham PK, Wang B, Trinh T, Christine A, Hong X, Nunes CN, Johnson CV, Zhang AS, Staskiewicz SJ, Braun M, Kumar S, Reddy VB. Zou Y, et al. Among authors: kumar s. Drug Metab Dispos. 2013 Dec;41(12):2206-14. doi: 10.1124/dmd.113.051524. Epub 2013 Oct 2. Drug Metab Dispos. 2013. PMID: 24088325

3

Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates.

Feng B, Pemberton R, Dworakowski W, Ye Z, Zetterberg C, Wang G, Morikawa Y, Kumar S. Feng B, et al. Among authors: kumar s. Drug Metab Dispos. 2021 Mar;49(3):254-264. doi: 10.1124/dmd.120.000276. Epub 2020 Dec 29. Drug Metab Dispos. 2021. PMID: 33376106

4

Glutathione S-transferase catalyzed desulfonylation of a sulfonylfuropyridine.

Bateman TJ, Debenham JS, Madsen-Duggan C, Toupence RB, Walsh TF, Truong Q, Bradley SA, Doss GA, Kumar S, Reddy VB. Bateman TJ, et al. Among authors: kumar s. Drug Metab Dispos. 2010 Jan;38(1):108-14. doi: 10.1124/dmd.109.029801. Drug Metab Dispos. 2010. PMID: 19797605

5

Metabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans.

Karanam B, Addy C, Bateman T, Reddy VB, Li S, Dean D, Li H, Jones A, Schenk D, Zhang AS, Braun M, Freeman A, Flach S, Stoch A, Chodakewitz J, Wagner JA, Kumar S. Karanam B, et al. Among authors: kumar s. Xenobiotica. 2010 Oct;40(10):691-700. doi: 10.3109/00498254.2010.509820. Xenobiotica. 2010. PMID: 20722472

6

Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans.

Kumar S, Tan EY, Hartmann G, Biddle Z, Bergman AJ, Dru J, Ho JZ, Jones AN, Staskiewicz SJ, Braun MP, Karanam B, Dean DC, Gendrano IN, Graves MW, Wagner JA, Krishna R. Kumar S, et al. Drug Metab Dispos. 2010 Mar;38(3):474-83. doi: 10.1124/dmd.109.028704. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016053 Clinical Trial.

7

A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

Yin W, Doss GA, Stearns RA, Chaudhary AG, Hop CE, Franklin RB, Kumar S. Yin W, et al. Among authors: kumar s. Drug Metab Dispos. 2003 Feb;31(2):215-23. doi: 10.1124/dmd.31.2.215. Drug Metab Dispos. 2003. PMID: 12527703

8

N-acetylation of the glutamate residue of intact glutathione conjugates in rats: a novel pathway for the metabolic processing of thiol adducts of xenobiotics.

Yin W, Doss GA, Stearns RA, Kumar S. Yin W, et al. Among authors: kumar s. Drug Metab Dispos. 2004 Jan;32(1):43-8. doi: 10.1124/dmd.32.1.43. Drug Metab Dispos. 2004. PMID: 14709619

9

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

Hop CE, Wang Y, Kumar S, Elipe MV, Raab CE, Dean DC, Poon GK, Keohane CA, Strauss J, Chiu SH, Curtis N, Elliott J, Gerhard U, Locker K, Morrison D, Mortishire-Smith R, Thomas S, Watt AP, Evans DC. Hop CE, et al. Among authors: kumar s. Drug Metab Dispos. 2002 Aug;30(8):937-43. doi: 10.1124/dmd.30.8.937. Drug Metab Dispos. 2002. PMID: 12124313

10

Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.

Tan EY, Hartmann G, Chen Q, Pereira A, Bradley S, Doss G, Zhang AS, Ho JZ, Braun MP, Dean DC, Tang W, Kumar S. Tan EY, et al. Among authors: kumar s. Drug Metab Dispos. 2010 Mar;38(3):459-73. doi: 10.1124/dmd.109.028696. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016052

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