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Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.
Voorneveld PW, Kodach LL, Jacobs RJ, Liv N, Zonnevylle AC, Hoogenboom JP, Biemond I, Verspaget HW, Hommes DW, de Rooij K, van Noesel CJ, Morreau H, van Wezel T, Offerhaus GJ, van den Brink GR, Peppelenbosch MP, Ten Dijke P, Hardwick JC. Voorneveld PW, et al. Among authors: offerhaus gj. Gastroenterology. 2014 Jul;147(1):196-208.e13. doi: 10.1053/j.gastro.2014.03.052. Epub 2014 Apr 3. Gastroenterology. 2014. PMID: 24704720
The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJ, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJ, Hardwick JC. Kodach LL, et al. Among authors: offerhaus gj. Gastroenterology. 2008 May;134(5):1332-41. doi: 10.1053/j.gastro.2008.02.059. Epub 2008 Mar 4. Gastroenterology. 2008. PMID: 18471510
Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation.
Vasen HF, Wasser M, van Mil A, Tollenaar RA, Konstantinovski M, Gruis NA, Bergman W, Hes FJ, Hommes DW, Offerhaus GJ, Morreau H, Bonsing BA, de Vos tot Nederveen Cappel WH. Vasen HF, et al. Among authors: offerhaus gj. Gastroenterology. 2011 Mar;140(3):850-6. doi: 10.1053/j.gastro.2010.11.048. Epub 2010 Dec 1. Gastroenterology. 2011. PMID: 21129377
Adenomas in patients with inflammatory bowel disease are associated with an increased risk of advanced neoplasia.
van Schaik FD, Mooiweer E, van der Have M, Belderbos TD, Ten Kate FJ, Offerhaus GJ, Schipper ME, Dijkstra G, Pierik M, Stokkers PC, Ponsioen C, de Jong DJ, Hommes DW, van Bodegraven AA, Siersema PD, van Oijen MG, Oldenburg B; Dutch Initiative on Crohn Colitis. van Schaik FD, et al. Among authors: offerhaus gj. Inflamm Bowel Dis. 2013 Feb;19(2):342-9. doi: 10.1097/MIB.0b013e318286f771. Inflamm Bowel Dis. 2013. PMID: 23340679
457 results