McMurray JS - Search Results

1

Structure-Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3).

Mandal PK, Ren Z, Chen X, Kaluarachchi K, Liao WS, McMurray JS. Mandal PK, et al. Among authors: mcmurray js. Int J Pept Res Ther. 2013 Mar;19(1):3-12. doi: 10.1007/s10989-012-9313-0. Int J Pept Res Ther. 2013. PMID: 24707243 Free PMC article.

2

Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor.

Coleman DR 4th, Ren Z, Mandal PK, Cameron AG, Dyer GA, Muranjan S, Campbell M, Chen X, McMurray JS. Coleman DR 4th, et al. Among authors: mcmurray js. J Med Chem. 2005 Oct 20;48(21):6661-70. doi: 10.1021/jm050513m. J Med Chem. 2005. PMID: 16220982

3

Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.

Mandal PK, Limbrick D, Coleman DR, Dyer GA, Ren Z, Birtwistle JS, Xiong C, Chen X, Briggs JM, McMurray JS. Mandal PK, et al. Among authors: mcmurray js. J Med Chem. 2009 Apr 23;52(8):2429-42. doi: 10.1021/jm801491w. J Med Chem. 2009. PMID: 19334714 Free PMC article.

4

Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3.

Mandal PK, Liao WS, McMurray JS. Mandal PK, et al. Among authors: mcmurray js. Org Lett. 2009 Aug 6;11(15):3394-7. doi: 10.1021/ol9012662. Org Lett. 2009. PMID: 19594124 Free PMC article.

5

Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.

Mandal PK, Ren Z, Chen X, Xiong C, McMurray JS. Mandal PK, et al. Among authors: mcmurray js. J Med Chem. 2009 Oct 8;52(19):6126-41. doi: 10.1021/jm901105k. J Med Chem. 2009. PMID: 19728728 Free PMC article.

6

Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.

Mandal PK, Gao F, Lu Z, Ren Z, Ramesh R, Birtwistle JS, Kaluarachchi KK, Chen X, Bast RC Jr, Liao WS, McMurray JS. Mandal PK, et al. Among authors: mcmurray js. J Med Chem. 2011 May 26;54(10):3549-63. doi: 10.1021/jm2000882. Epub 2011 Apr 26. J Med Chem. 2011. PMID: 21486047 Free PMC article.

7

A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis.

Auzenne EJ, Klostergaard J, Mandal PK, Liao WS, Lu Z, Gao F, Bast RC Jr, Robertson FM, McMurray JS. Auzenne EJ, et al. Among authors: mcmurray js. J Exp Ther Oncol. 2012;10(2):155-62. J Exp Ther Oncol. 2012. PMID: 23350355 Free PMC article.

8

The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain.

McMurray JS, Mandal PK, Liao WS, Klostergaard J, Robertson FM. McMurray JS, et al. JAKSTAT. 2012 Oct 1;1(4):263-347. doi: 10.4161/jkst.22682. JAKSTAT. 2012. PMID: 24058783 Free PMC article. Review.

9

Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6.

Morlacchi P, Mandal PK, McMurray JS. Morlacchi P, et al. Among authors: mcmurray js. ACS Med Chem Lett. 2013 Dec 4;5(1):69-72. doi: 10.1021/ml4003919. eCollection 2014 Jan 9. ACS Med Chem Lett. 2013. PMID: 24900775 Free PMC article.

10

Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics.

Mandal PK, Heard PA, Ren Z, Chen X, McMurray JS. Mandal PK, et al. Among authors: mcmurray js. Bioorg Med Chem Lett. 2007 Feb 1;17(3):654-6. doi: 10.1016/j.bmcl.2006.10.099. Epub 2006 Nov 6. Bioorg Med Chem Lett. 2007. PMID: 17113289 Free PMC article.

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