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Page 1
Abnormal visual gain control in a Parkinson's disease model.
Afsari F, Christensen KV, Smith GP, Hentzer M, Nippe OM, Elliott CJ, Wade AR. Afsari F, et al. Among authors: hentzer m. Hum Mol Genet. 2014 Sep 1;23(17):4465-78. doi: 10.1093/hmg/ddu159. Epub 2014 Apr 9. Hum Mol Genet. 2014. PMID: 24718285 Free PMC article.
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.
Smith GP, Badolo L, Chell V, Chen IJ, Christensen KV, David L, Daechsel JA, Hentzer M, Herzig MC, Mikkelsen GK, Watson SP, Williamson DS. Smith GP, et al. Among authors: hentzer m. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4500-4505. doi: 10.1016/j.bmcl.2017.07.072. Epub 2017 Aug 1. Bioorg Med Chem Lett. 2017. PMID: 28802631
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
Williamson DS, Smith GP, Acheson-Dossang P, Bedford ST, Chell V, Chen IJ, Daechsel JCA, Daniels Z, David L, Dokurno P, Hentzer M, Herzig MC, Hubbard RE, Moore JD, Murray JB, Newland S, Ray SC, Shaw T, Surgenor AE, Terry L, Thirstrup K, Wang Y, Christensen KV. Williamson DS, et al. Among authors: hentzer m. J Med Chem. 2017 Nov 9;60(21):8945-8962. doi: 10.1021/acs.jmedchem.7b01186. Epub 2017 Oct 27. J Med Chem. 2017. PMID: 29023112 Free article.
Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
Williamson DS, Smith GP, Mikkelsen GK, Jensen T, Acheson-Dossang P, Badolo L, Bedford ST, Chell V, Chen IJ, Dokurno P, Hentzer M, Newland S, Ray SC, Shaw T, Surgenor AE, Terry L, Wang Y, Christensen KV. Williamson DS, et al. Among authors: hentzer m. J Med Chem. 2021 Jul 22;64(14):10312-10332. doi: 10.1021/acs.jmedchem.1c00720. Epub 2021 Jun 29. J Med Chem. 2021. PMID: 34184879 Free article.
Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.
Maeda K, Sugino H, Akazawa H, Amada N, Shimada J, Futamura T, Yamashita H, Ito N, McQuade RD, Mørk A, Pehrson AL, Hentzer M, Nielsen V, Bundgaard C, Arnt J, Stensbøl TB, Kikuchi T. Maeda K, et al. Among authors: hentzer m. J Pharmacol Exp Ther. 2014 Sep;350(3):589-604. doi: 10.1124/jpet.114.213793. Epub 2014 Jun 19. J Pharmacol Exp Ther. 2014. PMID: 24947465
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.
Sams AG, Hentzer M, Mikkelsen GK, Larsen K, Bundgaard C, Plath N, Christoffersen CT, Bang-Andersen B. Sams AG, et al. Among authors: hentzer m. J Med Chem. 2010 Sep 9;53(17):6386-97. doi: 10.1021/jm100697g. J Med Chem. 2010. PMID: 20684563
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