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Mapping the cellular response to small molecules using chemogenomic fitness signatures.
Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G. Lee AY, et al. Among authors: wu y. Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Science. 2014. PMID: 24723613 Free PMC article.
Mitochondrial DNA damage by bleomycin induces AML cell death.
Yeung M, Hurren R, Nemr C, Wang X, Hershenfeld S, Gronda M, Liyanage S, Wu Y, Augustine J, Lee EA, Spagnuolo PA, Southall N, Chen C, Zheng W, Jeyaraju DV, Minden MD, Laposa R, Schimmer AD. Yeung M, et al. Among authors: wu y. Apoptosis. 2015 Jun;20(6):811-20. doi: 10.1007/s10495-015-1119-z. Apoptosis. 2015. PMID: 25820141
Mitochondrial carrier homolog 2 is necessary for AML survival.
Khan DH, Mullokandov M, Wu Y, Voisin V, Gronda M, Hurren R, Wang X, MacLean N, Jeyaraju DV, Jitkova Y, Xu GW, Laister R, Seneviratne A, Blatman ZM, Ketela T, Bader GD, Marhon SA, De Carvalho DD, Minden MD, Gross A, Schimmer AD. Khan DH, et al. Among authors: wu y. Blood. 2020 Jul 2;136(1):81-92. doi: 10.1182/blood.2019000106. Blood. 2020. PMID: 32299104 Free article.
A specificity map for the PDZ domain family.
Tonikian R, Zhang Y, Sazinsky SL, Currell B, Yeh JH, Reva B, Held HA, Appleton BA, Evangelista M, Wu Y, Xin X, Chan AC, Seshagiri S, Lasky LA, Sander C, Boone C, Bader GD, Sidhu SS. Tonikian R, et al. Among authors: wu y. PLoS Biol. 2008 Sep 30;6(9):e239. doi: 10.1371/journal.pbio.0060239. PLoS Biol. 2008. PMID: 18828675 Free PMC article.
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