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DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.
Aleyasin H, Rousseaux MW, Marcogliese PC, Hewitt SJ, Irrcher I, Joselin AP, Parsanejad M, Kim RH, Rizzu P, Callaghan SM, Slack RS, Mak TW, Park DS. Aleyasin H, et al. Among authors: marcogliese pc. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3186-91. doi: 10.1073/pnas.0914876107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133695 Free PMC article.
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.
Rousseaux MW, Marcogliese PC, Qu D, Hewitt SJ, Seang S, Kim RH, Slack RS, Schlossmacher MG, Lagace DC, Mak TW, Park DS. Rousseaux MW, et al. Among authors: marcogliese pc. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15918-23. doi: 10.1073/pnas.1205102109. Epub 2012 Sep 10. Proc Natl Acad Sci U S A. 2012. PMID: 23019375 Free PMC article.
BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.
Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MW, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, Park DS. Qu D, et al. Among authors: marcogliese pc. J Biol Chem. 2015 Dec 18;290(51):30441-52. doi: 10.1074/jbc.M115.677815. Epub 2015 Nov 4. J Biol Chem. 2015. PMID: 26538564 Free PMC article.
Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
Kim KS, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE; Canadian Lrrk2 in Inflammation Team (CLINT); Park DS. Kim KS, et al. Among authors: marcogliese pc. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5164-E5173. doi: 10.1073/pnas.1718946115. Epub 2018 May 14. Proc Natl Acad Sci U S A. 2018. PMID: 29760073 Free PMC article.
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Shutinoski B, Hakimi M, Harmsen IE, Lunn M, Rocha J, Lengacher N, Zhou YY, Khan J, Nguyen A, Hake-Volling Q, El-Kodsi D, Li J, Alikashani A, Beauchamp C, Majithia J, Coombs K, Shimshek D, Marcogliese PC, Park DS, Rioux JD, Philpott DJ, Woulfe JM, Hayley S, Sad S, Tomlinson JJ, Brown EG, Schlossmacher MG. Shutinoski B, et al. Among authors: marcogliese pc. Sci Transl Med. 2019 Sep 25;11(511):eaas9292. doi: 10.1126/scitranslmed.aas9292. Sci Transl Med. 2019. PMID: 31554740
De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment.
Dutta D, Briere LC, Kanca O, Marcogliese PC, Walker MA, High FA, Vanderver A, Krier J, Carmichael N, Callahan C, Taft RJ, Simons C, Helman G, Network UD, Wangler MF, Yamamoto S, Sweetser DA, Bellen HJ. Dutta D, et al. Among authors: marcogliese pc. Hum Mol Genet. 2020 Jun 3;29(9):1568-1579. doi: 10.1093/hmg/ddaa081. Hum Mol Genet. 2020. PMID: 32356556 Free PMC article.
33 results