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The rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy.
Orqueda AJ, Dansey MV, Español A, Veleiro AS, Bal de Kier Joffé E, Sales ME, Burton G, Pecci A. Orqueda AJ, et al. Among authors: bal de kier joffe e. Biochem Pharmacol. 2014 Jun 15;89(4):526-35. doi: 10.1016/j.bcp.2014.04.006. Epub 2014 Apr 13. Biochem Pharmacol. 2014. PMID: 24735610 Free article.
Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability.
Guerra FK, Eijan AM, Puricelli L, Alonso DF, Bal de Kier Joffé E, Kornblihgtt AR, Charreau EH, Elizalde PV. Guerra FK, et al. Among authors: bal de kier joffe e. Int J Cancer. 1996 Mar 15;65(6):812-20. doi: 10.1002/(SICI)1097-0215(19960315)65:6<812::AID-IJC18>3.0.CO;2-5. Int J Cancer. 1996. PMID: 8631597
Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways.
Carnevale RP, Proietti CJ, Salatino M, Urtreger A, Peluffo G, Edwards DP, Boonyaratanakornkit V, Charreau EH, Bal de Kier Joffé E, Schillaci R, Elizalde PV. Carnevale RP, et al. Among authors: bal de kier joffe e. Mol Endocrinol. 2007 Jun;21(6):1335-58. doi: 10.1210/me.2006-0304. Epub 2007 Apr 17. Mol Endocrinol. 2007. PMID: 17440047
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