Leal SM - Search Results

1

Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity.

Álvarez G, Varela J, Márquez P, Gabay M, Arias Rivas CE, Cuchilla K, Echeverría GA, Piro OE, Chorilli M, Leal SM, Escobar P, Serna E, Torres S, Yaluff G, Vera de Bilbao NI, González M, Cerecetto H. Álvarez G, et al. Among authors: leal sm. J Med Chem. 2014 May 22;57(10):3984-99. doi: 10.1021/jm500018m. Epub 2014 May 2. J Med Chem. 2014. PMID: 24749923

2

Identification of a new amide-containing thiazole as a drug candidate for treatment of Chagas' disease.

Álvarez G, Varela J, Cruces E, Fernández M, Gabay M, Leal SM, Escobar P, Sanabria L, Serna E, Torres S, Figueredo Thiel SJ, Yaluff G, Vera de Bilbao NI, Cerecetto H, González M. Álvarez G, et al. Among authors: leal sm. Antimicrob Agents Chemother. 2015 Mar;59(3):1398-404. doi: 10.1128/AAC.03814-14. Epub 2014 Dec 15. Antimicrob Agents Chemother. 2015. PMID: 25512408 Free PMC article.

3

Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo.

Álvarez G, Martínez J, Varela J, Birriel E, Cruces E, Gabay M, Leal SM, Escobar P, Aguirre-López B, Cabrera N, Tuena de Gómez-Puyou M, Gómez Puyou A, Pérez-Montfort R, Yaluff G, Torres S, Serna E, Vera de Bilbao N, González M, Cerecetto H. Álvarez G, et al. Among authors: leal sm. Eur J Med Chem. 2015 Jul 15;100:246-56. doi: 10.1016/j.ejmech.2015.06.018. Epub 2015 Jun 12. Eur J Med Chem. 2015. PMID: 26094151

4

Synthesis, structural elucidation and in vitro antiparasitic activity against Trypanosoma cruzi and Leishmania chagasi parasites of novel tetrahydro-1-benzazepine derivatives.

Gómez-Ayala S, Castrillón JA, Palma A, Leal SM, Escobar P, Bahsas A. Gómez-Ayala S, et al. Among authors: leal sm. Bioorg Med Chem. 2010 Jul 1;18(13):4721-39. doi: 10.1016/j.bmc.2010.05.018. Epub 2010 May 7. Bioorg Med Chem. 2010. PMID: 20627590

5

Synthesis of novel polysubstituted (2SR,4RS)-2-heteroaryltetrahydro-1,4-epoxy-1-benzazepines and cis-2-heteroaryl-4-hydroxytetrahydro-1H-1-benzazepines as antiparasitic agents.

Blanco MC, Escobar P, Leal SM, Bahsas A, Cobo J, Nogueras M, Palma A. Blanco MC, et al. Among authors: leal sm. Eur J Med Chem. 2014 Oct 30;86:291-309. doi: 10.1016/j.ejmech.2014.08.055. Epub 2014 Aug 17. Eur J Med Chem. 2014. PMID: 25173828

6

Synthesis and in vitro activity of new tetrahydronaphtho[1,2-b]azepine derivatives against Trypanosoma cruzi and Leishmania chagasi parasites.

Palma A, Yépes AF, Leal SM, Coronado CA, Escobar P. Palma A, et al. Among authors: leal sm. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2360-3. doi: 10.1016/j.bmcl.2008.05.013. Epub 2008 May 6. Bioorg Med Chem Lett. 2009. PMID: 19321339

7

Vanadium polypyridyl compounds as potential antiparasitic and antitumoral agents: new achievements.

Benítez J, Becco L, Correia I, Leal SM, Guiset H, Pessoa JC, Lorenzo J, Tanco S, Escobar P, Moreno V, Garat B, Gambino D. Benítez J, et al. Among authors: leal sm. J Inorg Biochem. 2011 Feb;105(2):303-12. doi: 10.1016/j.jinorgbio.2010.11.001. Epub 2010 Nov 12. J Inorg Biochem. 2011. PMID: 21194632

8

Acute Chagas outbreaks: molecular and biological features of Trypanosoma cruzi isolates, and clinical aspects of acute cases in Santander, Colombia.

Díaz ML, Leal S, Mantilla JC, Molina-Berríos A, López-Muñoz R, Solari A, Escobar P, González Rugeles CI. Díaz ML, et al. Parasit Vectors. 2015 Nov 26;8:608. doi: 10.1186/s13071-015-1218-2. Parasit Vectors. 2015. PMID: 26612724 Free PMC article.

9

In vitro antileishmanial, trypanocidal, and Mammalian cell activities of diverse n,n' -dihetaryl substituted diamines and related compounds.

Leal SM, Amado DF, Kouznetsov VV, Escobar P. Leal SM, et al. Sci Pharm. 2013 Jan-Mar;81(1):43-55. doi: 10.3797/scipharm.1205-14. Epub 2012 Oct 14. Sci Pharm. 2013. PMID: 23641328 Free PMC article.

10

Composition of three essential oils, and their mammalian cell toxicity and antimycobacterial activity against drug resistant-tuberculosis and nontuberculous mycobacteria strains.

Bueno J, Escobar P, Martínez JR, Leal SM, Stashenko EE. Bueno J, et al. Among authors: leal sm. Nat Prod Commun. 2011 Nov;6(11):1743-8. Nat Prod Commun. 2011. PMID: 22224302

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