Groothuis G - Search Results

1

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Fredriksson L, et al. Among authors: groothuis g. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20. Toxicol Sci. 2014. PMID: 24752500

2

The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.

Olinga P, Hof IH, Merema MT, Smit M, de Jager MH, Swart PJ, Slooff MJ, Meijer DK, Groothuis GM. Olinga P, et al. Among authors: groothuis gm. J Pharmacol Toxicol Methods. 2001 Jan-Feb;45(1):55-63. doi: 10.1016/s1056-8719(01)00127-7. J Pharmacol Toxicol Methods. 2001. PMID: 11489665

3

Rat liver slices as a tool to study LPS-induced inflammatory response in the liver.

Olinga P, Merema MT, de Jager MH, Derks F, Melgert BN, Moshage H, Slooff MJ, Meijer DK, Poelstra K, Groothuis GM. Olinga P, et al. Among authors: groothuis gm. J Hepatol. 2001 Aug;35(2):187-94. doi: 10.1016/s0168-8278(01)00103-9. J Hepatol. 2001. PMID: 11580140

4

Comparison of five incubation systems for rat liver slices using functional and viability parameters.

Olinga P, Groen K, Hof IH, De Kanter R, Koster HJ, Leeman WR, Rutten AA, Van Twillert K, Groothuis GM. Olinga P, et al. Among authors: groothuis gm. J Pharmacol Toxicol Methods. 1997 Oct;38(2):59-69. doi: 10.1016/s1056-8719(97)00060-9. J Pharmacol Toxicol Methods. 1997. PMID: 9403776

5

Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro.

Nijsten MW, Olinga P, The TH, de Vries EG, Koops HS, Groothuis GM, Limburg PC, ten Duis HJ, Moshage H, Hoekstra HJ, Bijzet J, Zwaveling JH. Nijsten MW, et al. Among authors: groothuis gm. Crit Care Med. 2000 Feb;28(2):458-61. doi: 10.1097/00003246-200002000-00028. Crit Care Med. 2000. PMID: 10708183

6

Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats.

Melgert BN, Olinga P, Van Der Laan JM, Weert B, Cho J, Schuppan D, Groothuis GM, Meijer DK, Poelstra K. Melgert BN, et al. Among authors: groothuis gm. Hepatology. 2001 Oct;34(4 Pt 1):719-28. doi: 10.1053/jhep.2001.27805. Hepatology. 2001. PMID: 11584368

7

Differentiation of human-induced pluripotent stem cell under flow conditions to mature hepatocytes for liver tissue engineering.

Starokozhko V, Hemmingsen M, Larsen L, Mohanty S, Merema M, Pimentel RC, Wolff A, Emnéus J, Aspegren A, Groothuis G, Dufva M. Starokozhko V, et al. Among authors: groothuis g. J Tissue Eng Regen Med. 2018 May;12(5):1273-1284. doi: 10.1002/term.2659. Epub 2018 Apr 6. J Tissue Eng Regen Med. 2018. PMID: 29499107 Free PMC article.

8

Precision-cut tissue slices as a tool to predict metabolism of novel drugs.

Graaf IA, Groothuis GM, Olinga P. Graaf IA, et al. Expert Opin Drug Metab Toxicol. 2007 Dec;3(6):879-98. doi: 10.1517/17425255.3.6.879. Expert Opin Drug Metab Toxicol. 2007. PMID: 18028031 Review.

9

Drug traffic in the hepatobiliary system.

Groothuis GM, Meijer DK. Groothuis GM, et al. J Hepatol. 1996;24 Suppl 1:3-28. J Hepatol. 1996. PMID: 8926366 Review. No abstract available.

10

Characterization of transport in isolated human hepatocytes. A study with the bile acid taurocholic acid, the uncharged ouabain and the organic cations vecuronium and rocuronium.

Sandker GW, Weert B, Olinga P, Wolters H, Slooff MJ, Meijer DK, Groothuis GM. Sandker GW, et al. Among authors: groothuis gm. Biochem Pharmacol. 1994 Jun 15;47(12):2193-200. doi: 10.1016/0006-2952(94)90255-0. Biochem Pharmacol. 1994. PMID: 7913319

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