de Bont H - Search Results

1

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Fredriksson L, et al. Among authors: de bont h. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20. Toxicol Sci. 2014. PMID: 24752500

2

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis.

Fredriksson L, Herpers B, Benedetti G, Matadin Q, Puigvert JC, de Bont H, Dragovic S, Vermeulen NP, Commandeur JN, Danen E, de Graauw M, van de Water B. Fredriksson L, et al. Among authors: de graauw m, de bont h. Hepatology. 2011 Jun;53(6):2027-41. doi: 10.1002/hep.24314. Hepatology. 2011. PMID: 21433042

3

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.

Herpers B, Wink S, Fredriksson L, Di Z, Hendriks G, Vrieling H, de Bont H, van de Water B. Herpers B, et al. Among authors: de bont h. Arch Toxicol. 2016 May;90(5):1163-79. doi: 10.1007/s00204-015-1536-3. Epub 2015 May 31. Arch Toxicol. 2016. PMID: 26026609 Free PMC article.

4

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability.

Hiemstra S, Ramaiahgari SC, Wink S, Callegaro G, Coonen M, Meerman J, Jennen D, van den Nieuwendijk K, Dankers A, Snoeys J, de Bont H, Price L, van de Water B. Hiemstra S, et al. Among authors: de bont h. Arch Toxicol. 2019 Oct;93(10):2895-2911. doi: 10.1007/s00204-019-02552-0. Epub 2019 Aug 27. Arch Toxicol. 2019. PMID: 31552476

5

High-throughput live cell imaging of apoptosis.

Puigvert JC, de Bont H, van de Water B, Danen EH. Puigvert JC, et al. Among authors: de bont h. Curr Protoc Cell Biol. 2010 Jun;Chapter 18:Unit 18.10.1-13. doi: 10.1002/0471143030.cb1810s47. Curr Protoc Cell Biol. 2010. PMID: 20521231

6

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.

Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, van de Water B. Zhang Y, et al. Among authors: de bont h. Breast Cancer Res. 2011 May 19;13(3):R52. doi: 10.1186/bcr2883. Breast Cancer Res. 2011. PMID: 21595894 Free PMC article.

7

FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells.

He J, Wink S, de Bont H, Le Dévédec S, Zhang Y, van de Water B. He J, et al. Among authors: de bont h. Biochem Pharmacol. 2019 Nov;169:113640. doi: 10.1016/j.bcp.2019.113640. Epub 2019 Sep 16. Biochem Pharmacol. 2019. PMID: 31536726 Free article.

8

Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.

van Miltenburg MH, Lalai R, de Bont H, van Waaij E, Beggs H, Danen EH, van de Water B. van Miltenburg MH, et al. Among authors: de bont h. FASEB J. 2009 Oct;23(10):3482-93. doi: 10.1096/fj.08-123398. Epub 2009 Jul 7. FASEB J. 2009. PMID: 19584305

9

Two-photon intravital multicolor imaging combined with inducible gene expression to distinguish metastatic behavior of breast cancer cells in vivo.

Le Dévédec SE, Lalai R, Pont C, de Bont H, van de Water B. Le Dévédec SE, et al. Among authors: de bont h. Mol Imaging Biol. 2011 Feb;13(1):67-77. doi: 10.1007/s11307-010-0307-z. Mol Imaging Biol. 2011. PMID: 20396956 Free PMC article.

10

Systems microscopy approaches to understand cancer cell migration and metastasis.

Le Dévédec SE, Yan K, de Bont H, Ghotra V, Truong H, Danen EH, Verbeek F, van de Water B. Le Dévédec SE, et al. Among authors: de bont h. Cell Mol Life Sci. 2010 Oct;67(19):3219-40. doi: 10.1007/s00018-010-0419-2. Epub 2010 Jun 18. Cell Mol Life Sci. 2010. PMID: 20556632 Free PMC article. Review.

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