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Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.
Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Fredriksson L, et al. Among authors: van de water b, de graauw m, de bont h. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20. Toxicol Sci. 2014. PMID: 24752500
Mitochondrial K+ as modulator of Ca(2+)-dependent cytotoxicity in hepatocytes. Novel application of the K(+)-sensitive dye PBFI (K(+)-binding benzofuran isophthalate) to assess free mitochondrial K+ concentrations.
Zoeteweij JP, van de Water B, de Bont HJ, Nagelkerke JF. Zoeteweij JP, et al. Among authors: de bont hj, van de water b. Biochem J. 1994 Apr 15;299 ( Pt 2)(Pt 2):539-43. doi: 10.1042/bj2990539. Biochem J. 1994. PMID: 8172616 Free PMC article.
Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium.
Zoeteweij JP, van de Water B, de Bont HJ, Mulder GJ, Nagelkerke JF. Zoeteweij JP, et al. Among authors: de bont hj, van de water b. J Biol Chem. 1993 Feb 15;268(5):3384-8. J Biol Chem. 1993. PMID: 8429014 Free article.
Rat hepatocytes were incubated with ATP to induce a sustained increase in intracellular Ca2+ ([Ca2+]i), dissipation of the mitochondrial membrane potential, and cell death (Zoeteweij, J. P., van de Water, B., de Bont, H. J. G. M., Mulder, G. J., …
Rat hepatocytes were incubated with ATP to induce a sustained increase in intracellular Ca2+ ([Ca2+]i), dissipation of the mitochondrial mem …
262 results