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Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state.
Milenkovic D, Vanden Berghe W, Boby C, Leroux C, Declerck K, Szarc vel Szic K, Heyninck K, Laukens K, Bizet M, Defrance M, Dedeurwaerder S, Calonne E, Fuks F, Haegeman G, Haenen GR, Bast A, Weseler AR. Milenkovic D, et al. Among authors: declerck k. PLoS One. 2014 Apr 24;9(4):e95527. doi: 10.1371/journal.pone.0095527. eCollection 2014. PLoS One. 2014. PMID: 24763279 Free PMC article.
Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells.
Szarc vel Szic K, Op de Beeck K, Ratman D, Wouters A, Beck IM, Declerck K, Heyninck K, Fransen E, Bracke M, De Bosscher K, Lardon F, Van Camp G, Vanden Berghe W. Szarc vel Szic K, et al. Among authors: declerck k. PLoS One. 2014 Feb 3;9(2):e87850. doi: 10.1371/journal.pone.0087850. eCollection 2014. PLoS One. 2014. PMID: 24498382 Free PMC article.
(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation.
Milenkovic D, Declerck K, Guttman Y, Kerem Z, Claude S, Weseler AR, Bast A, Schroeter H, Morand C, Vanden Berghe W. Milenkovic D, et al. Among authors: declerck k. Biochem Pharmacol. 2020 Mar;173:113699. doi: 10.1016/j.bcp.2019.113699. Epub 2019 Nov 20. Biochem Pharmacol. 2020. PMID: 31756325 Free article.
Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease.
Istas G, Declerck K, Pudenz M, Szic KSV, Lendinez-Tortajada V, Leon-Latre M, Heyninck K, Haegeman G, Casasnovas JA, Tellez-Plaza M, Gerhauser C, Heiss C, Rodriguez-Mateos A, Berghe WV. Istas G, et al. Among authors: declerck k. Sci Rep. 2017 Jul 11;7(1):5120. doi: 10.1038/s41598-017-03434-0. Sci Rep. 2017. PMID: 28698603 Free PMC article.
50 results