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Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.
Wang CQ, Krishnan V, Tay LS, Chin DW, Koh CP, Chooi JY, Nah GS, Du L, Jacob B, Yamashita N, Lai SK, Tan TZ, Mori S, Tanuichi I, Tergaonkar V, Ito Y, Osato M. Wang CQ, et al. Among authors: du l. Cell Rep. 2014 Aug 7;8(3):767-82. doi: 10.1016/j.celrep.2014.06.046. Epub 2014 Jul 24. Cell Rep. 2014. PMID: 25066130 Free article.
Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells.
Koh CP, Bahirvani AG, Wang CQ, Yokomizo T, Ng CEL, Du L, Tergaonkar V, Voon DC, Kitamura H, Hosoi H, Sonoki T, Michelle MMH, Tan LJ, Niibori-Nambu A, Zhang Y, Perkins AS, Hossain Z, Tenen DG, Ito Y, Venkatesh B, Osato M. Koh CP, et al. Among authors: du l. Gene. 2023 Jan 30;851:147049. doi: 10.1016/j.gene.2022.147049. Epub 2022 Nov 13. Gene. 2023. PMID: 36384171 Free PMC article.
Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia.
Ong KOK, Mok MMH, Niibori-Nambu A, Du L, Yanagida M, Wang CQ, Bahirvani AG, Chin DWL, Koh CP, Ng KP, Yamashita N, Jacob B, Yokomizo T, Takizawa H, Matsumura T, Suda T, Lau JA, Tan TZ, Mori S, Yang H, Iwasaki M, Minami T, Asou N, Sun QY, Ding LW, Koeffler HP, Tenen DG, Shimizu R, Yamamoto M, Ito Y, Kham SKY, Yeoh AE, Chng WJ, Osato M. Ong KOK, et al. Among authors: du l. Exp Hematol. 2024 Sep;137:104255. doi: 10.1016/j.exphem.2024.104255. Epub 2024 Jun 13. Exp Hematol. 2024. PMID: 38876252
Basic Science and Pathogenesis.
Du L, Langhough RE, Hermann BP, Betthauser TJ, Planalp EM, Jonaitis EM, Reyes RER, Rivera-Rivera LA, Cody KA, Chin NA, Cadman RV, Johnson KM, Field AS, Rowley HA, Pompa CC, Hudson SC, Ryther B, Sparks LJ, Miess B, Norris N, Ramsey CM, Mueller KD, Asthana S, Eisenmenger LB, Christian BT, Johnson SC. Du L, et al. Alzheimers Dement. 2024 Dec;20 Suppl 1:e089451. doi: 10.1002/alz.089451. Alzheimers Dement. 2024. PMID: 39751132
8,171 results