Frum R - Search Results

1

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.

Singh S, Vaughan CA, Frum RA, Grossman SR, Deb S, Palit Deb S. Singh S, et al. Among authors: frum ra. J Clin Invest. 2017 May 1;127(5):1839-1855. doi: 10.1172/JCI87724. Epub 2017 Apr 10. J Clin Invest. 2017. PMID: 28394262 Free PMC article.

2

Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.

Frum RA, Love IM, Damle PK, Mukhopadhyay ND, Palit Deb S, Deb S, Grossman SR. Frum RA, et al. Mol Cancer Res. 2016 May;14(5):423-36. doi: 10.1158/1541-7786.MCR-15-0363. Epub 2016 Mar 10. Mol Cancer Res. 2016. PMID: 26965143 Free PMC article.

3

Mechanisms of mutant p53 stabilization in cancer.

Frum RA, Grossman SR. Frum RA, et al. Subcell Biochem. 2014;85:187-97. doi: 10.1007/978-94-017-9211-0_10. Subcell Biochem. 2014. PMID: 25201195

4

Clinicopathologic and molecular characterization of myeloid neoplasms harboring isochromosome 17(q10).

Visconte V, Tabarroki A, Zhang L, Hasrouni E, Gerace C, Frum R, Ai J, Advani AS, Duong HK, Kalaycio M, Saunthararajah Y, Sekeres MA, His ED, Shetty S, Rogers HJ, Tiu RV. Visconte V, et al. Among authors: frum r. Am J Hematol. 2014 Aug;89(8):862. doi: 10.1002/ajh.23755. Epub 2014 May 16. Am J Hematol. 2014. PMID: 24796269 Free article. No abstract available.

5

The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing.

Frum RA, Singh S, Vaughan C, Mukhopadhyay ND, Grossman SR, Windle B, Deb S, Deb SP. Frum RA, et al. Nucleic Acids Res. 2014 Jan;42(2):926-40. doi: 10.1093/nar/gkt944. Epub 2013 Oct 24. Nucleic Acids Res. 2014. PMID: 24163099 Free PMC article.

6

Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl.

Vaughan CA, Singh S, Windle B, Yeudall WA, Frum R, Grossman SR, Deb SP, Deb S. Vaughan CA, et al. Among authors: frum r. Genes Cancer. 2012 Jul;3(7-8):491-502. doi: 10.1177/1947601912462719. Genes Cancer. 2012. PMID: 23264849 Free PMC article.

7

Use of the DNA fiber spreading technique to detect the effects of mutant p53 on DNA replication.

Frum RA, Deb S, Deb SP. Frum RA, et al. Methods Mol Biol. 2013;962:147-55. doi: 10.1007/978-1-62703-236-0_12. Methods Mol Biol. 2013. PMID: 23150444 Free PMC article.

8

Allele specific gain-of-function activity of p53 mutants in lung cancer cells.

Vaughan CA, Frum R, Pearsall I, Singh S, Windle B, Yeudall A, Deb SP, Deb S. Vaughan CA, et al. Among authors: frum r. Biochem Biophys Res Commun. 2012 Nov 9;428(1):6-10. doi: 10.1016/j.bbrc.2012.09.029. Epub 2012 Sep 16. Biochem Biophys Res Commun. 2012. PMID: 22989750 Free PMC article.

9

The RP-p53-Mdm2 pathway: a new link to genetic integrity?

Frum RA, Zhang Y. Frum RA, et al. Cell Cycle. 2010 Nov 15;9(22):4427. doi: 10.4161/cc.9.22.13606. Cell Cycle. 2010. PMID: 21135577 Free PMC article. No abstract available.

10

Temporal differences in DNA replication during the S phase using single fiber analysis of normal human fibroblasts and glioblastoma T98G cells.

Frum RA, Khondker ZS, Kaufman DG. Frum RA, et al. Cell Cycle. 2009 Oct 1;8(19):3133-48. doi: 10.4161/cc.8.19.9682. Cell Cycle. 2009. PMID: 19738421 Free PMC article.

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