Rose-John S - Search Results

1

The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).

Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J. Wagener EM, et al. J Biol Chem. 2014 Jun 27;289(26):18442-50. doi: 10.1074/jbc.M114.568857. Epub 2014 May 6. J Biol Chem. 2014. PMID: 24802752 Free PMC article.

2

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.

Ehlers M, Grötzinger J, deHon FD, Müllberg J, Brakenhoff JP, Liu J, Wollmer A, Rose-John S. Ehlers M, et al. J Immunol. 1994 Aug 15;153(4):1744-53. J Immunol. 1994. PMID: 7519211

3

The soluble interleukin-6 receptor.

Rose-John S, Ehlers M, Grötzinger J, Müllberg J. Rose-John S, et al. Ann N Y Acad Sci. 1995 Jul 21;762:207-20; discussion 220-1. Ann N Y Acad Sci. 1995. PMID: 7668529 No abstract available.

4

Residues 77-95 of the human interleuken-6 protein are responsible for receptor binding and residues 41-56 for signal transduction.

Ehlers M, Grötzinger J, de Hon FD, Müllberg J, Brakenhoff JP, Wollmer A, Rose-John S. Ehlers M, et al. Ann N Y Acad Sci. 1995 Jul 21;762:400-2. doi: 10.1111/j.1749-6632.1995.tb32347.x. Ann N Y Acad Sci. 1995. PMID: 7668541 No abstract available.

5

Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.

Ehlers M, de Hon FD, Bos HK, Horsten U, Kurapkat G, van De Leur HS, Grötzinger J, Wollmer A, Brakenhoff JP, Rose-John S. Ehlers M, et al. J Biol Chem. 1995 Apr 7;270(14):8158-63. doi: 10.1074/jbc.270.14.8158. J Biol Chem. 1995. PMID: 7713920 Free article.

6

Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.

Dittrich E, Rose-John S, Gerhartz C, Müllberg J, Stoyan T, Yasukawa K, Heinrich PC, Graeve L. Dittrich E, et al. J Biol Chem. 1994 Jul 22;269(29):19014-20. J Biol Chem. 1994. PMID: 8034658 Free article.

7

Development of a human interleukin-6 receptor antagonist.

Brakenhoff JP, de Hon FD, Fontaine V, ten Boekel E, Schooltink H, Rose-John S, Heinrich PC, Content J, Aarden LA. Brakenhoff JP, et al. J Biol Chem. 1994 Jan 7;269(1):86-93. J Biol Chem. 1994. PMID: 8276883 Free article.

8

Intracellular retention of interleukin-6 abrogates signaling.

Rose-John S, Schooltink H, Schmitz-Van de Leur H, Müllberg J, Heinrich PC, Graeve L. Rose-John S, et al. J Biol Chem. 1993 Oct 15;268(29):22084-91. J Biol Chem. 1993. PMID: 8408066 Free article.

9

Identification of single amino acid residues of human IL-6 involved in receptor binding and signal initiation.

Ehlers M, Grötzinger J, Fischer M, Bos HK, Brakenhoff JP, Rose-John S. Ehlers M, et al. J Interferon Cytokine Res. 1996 Aug;16(8):569-76. doi: 10.1089/jir.1996.16.569. J Interferon Cytokine Res. 1996. PMID: 8877726

10

Identification of residues in the putative 5th helical region of human interleukin-6, important for activation of the IL-6 signal transducer, gp130.

Brakenhoff JP, Bos HK, Grötzinger J, Rose-John S, Aarden LA. Brakenhoff JP, et al. FEBS Lett. 1996 Oct 21;395(2-3):235-40. doi: 10.1016/0014-5793(96)00974-x. FEBS Lett. 1996. PMID: 8898103 Free article.

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