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HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. Serrano-Villar S, et al. Among authors: meinert cl. PLoS Pathog. 2014 May 15;10(5):e1004078. doi: 10.1371/journal.ppat.1004078. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24831517 Free PMC article. Clinical Trial.
Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.
Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW. Lee SA, et al. Among authors: meinert cl. J Infect Dis. 2014 Aug 1;210(3):374-82. doi: 10.1093/infdis/jiu109. Epub 2014 Feb 28. J Infect Dis. 2014. PMID: 24585893 Free PMC article.
Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection.
Hunt PW, Sinclair E, Rodriguez B, Shive C, Clagett B, Funderburg N, Robinson J, Huang Y, Epling L, Martin JN, Deeks SG, Meinert CL, Van Natta ML, Jabs DA, Lederman MM. Hunt PW, et al. Among authors: meinert cl. J Infect Dis. 2014 Oct 15;210(8):1228-38. doi: 10.1093/infdis/jiu238. Epub 2014 Apr 21. J Infect Dis. 2014. PMID: 24755434 Free PMC article.
Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy.
Krauskopf K, Van Natta ML, Danis RP, Gangaputra S, Ackatz L, Addessi A, Federman AD, Branch AD, Meinert CL, Jabs DA; Studies of the Ocular Complications of AIDS Research Group. Krauskopf K, et al. Among authors: meinert cl. J Int Assoc Provid AIDS Care. 2013 Sep-Oct;12(5):325-33. doi: 10.1177/2325957413491432. J Int Assoc Provid AIDS Care. 2013. PMID: 23764503 Free PMC article.
150 results