Shen Q - Search Results

1

Small molecule inhibitors targeting activator protein 1 (AP-1).

Ye N, Ding Y, Wild C, Shen Q, Zhou J. Ye N, et al. Among authors: shen q. J Med Chem. 2014 Aug 28;57(16):6930-48. doi: 10.1021/jm5004733. Epub 2014 May 27. J Med Chem. 2014. PMID: 24831826 Free PMC article.

2

Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility.

Ding C, Zhang Y, Chen H, Yang Z, Wild C, Chu L, Liu H, Shen Q, Zhou J. Ding C, et al. Among authors: shen q. J Med Chem. 2013 Jun 27;56(12):5048-58. doi: 10.1021/jm400367n. Epub 2013 Jun 19. J Med Chem. 2013. PMID: 23746196 Free PMC article.

3

Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

Ding C, Zhang Y, Chen H, Yang Z, Wild C, Ye N, Ester CD, Xiong A, White MA, Shen Q, Zhou J. Ding C, et al. Among authors: shen q. J Med Chem. 2013 Nov 14;56(21):8814-25. doi: 10.1021/jm401248x. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24128046 Free PMC article.

4

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).

Chen H, Yang Z, Ding C, Xiong A, Wild C, Wang L, Ye N, Cai G, Flores RM, Ding Y, Shen Q, Zhou J. Chen H, et al. Among authors: shen q. Eur J Med Chem. 2014 Jul 23;82:195-203. doi: 10.1016/j.ejmech.2014.05.049. Epub 2014 May 22. Eur J Med Chem. 2014. PMID: 24904966 Free PMC article.

5

Discovery and development of natural product oridonin-inspired anticancer agents.

Ding Y, Ding C, Ye N, Liu Z, Wold EA, Chen H, Wild C, Shen Q, Zhou J. Ding Y, et al. Among authors: shen q. Eur J Med Chem. 2016 Oct 21;122:102-117. doi: 10.1016/j.ejmech.2016.06.015. Epub 2016 Jun 13. Eur J Med Chem. 2016. PMID: 27344488 Free PMC article. Review.

6

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy.

Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Chen H, et al. Among authors: shen q. Eur J Med Chem. 2013 Apr;62:498-507. doi: 10.1016/j.ejmech.2013.01.023. Epub 2013 Jan 26. Eur J Med Chem. 2013. PMID: 23416191 Free PMC article.

7

Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.

Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Chen H, et al. Among authors: shen q. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185. doi: 10.1021/ml3003082. Epub 2013 Jan 15. ACS Med Chem Lett. 2013. PMID: 23459613 Free PMC article.

8

ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids.

Ding C, Wang L, Chen H, Wild C, Ye N, Ding Y, Wang T, White MA, Shen Q, Zhou J. Ding C, et al. Among authors: shen q. Org Biomol Chem. 2014 Nov 14;12(42):8442-52. doi: 10.1039/c4ob01040j. Org Biomol Chem. 2014. PMID: 25225052 Free PMC article.

9

Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152.

Wang Y, Wang S, Wu Y, Ren Y, Li Z, Yao X, Zhang C, Ye N, Jing C, Dong J, Zhang K, Sun S, Zhao M, Guo W, Qu X, Qiao Y, Chen H, Kong L, Jin R, Wang X, Zhang L, Zhou J, Shen Q, Zhou X. Wang Y, et al. Among authors: shen q. Mol Cancer Ther. 2017 Apr;16(4):578-590. doi: 10.1158/1535-7163.MCT-16-0606. Epub 2017 Jan 30. Mol Cancer Ther. 2017. PMID: 28138036 Free PMC article.

10

Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection.

Xu J, Wold EA, Ding Y, Shen Q, Zhou J. Xu J, et al. Among authors: shen q. Molecules. 2018 Feb 22;23(2):474. doi: 10.3390/molecules23020474. Molecules. 2018. PMID: 29470395 Free PMC article. Review.

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