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Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists.
Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Toda N. Takano R, et al. Among authors: honda t. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2949-53. doi: 10.1016/j.bmcl.2014.04.065. Epub 2014 Apr 26. Bioorg Med Chem Lett. 2014. PMID: 24835985
Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists.
Nakashima R, Yano T, Ogawa J, Tanaka N, Toda N, Yoshida M, Takano R, Inoue M, Honda T, Kume S, Matsumoto K. Nakashima R, et al. Among authors: honda t. Eur J Pharmacol. 2014 Aug 15;737:194-201. doi: 10.1016/j.ejphar.2014.05.014. Epub 2014 May 22. Eur J Pharmacol. 2014. PMID: 24858371
Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.
Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Hirouchi M, Yoneyama T, Ito S, Toda N. Takano R, et al. Among authors: honda t. ACS Med Chem Lett. 2015 Jan 13;6(3):266-70. doi: 10.1021/ml500391n. eCollection 2015 Mar 12. ACS Med Chem Lett. 2015. PMID: 25815144 Free PMC article.
3,449 results