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Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists.
Nakashima R, Yano T, Ogawa J, Tanaka N, Toda N, Yoshida M, Takano R, Inoue M, Honda T, Kume S, Matsumoto K. Nakashima R, et al. Among authors: takano r. Eur J Pharmacol. 2014 Aug 15;737:194-201. doi: 10.1016/j.ejphar.2014.05.014. Epub 2014 May 22. Eur J Pharmacol. 2014. PMID: 24858371
Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.
Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Hirouchi M, Yoneyama T, Ito S, Toda N. Takano R, et al. ACS Med Chem Lett. 2015 Jan 13;6(3):266-70. doi: 10.1021/ml500391n. eCollection 2015 Mar 12. ACS Med Chem Lett. 2015. PMID: 25815144 Free PMC article.
A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.
Noguchi T, Umezaki Y, Takano R, Fujimoto T, Domon Y, Kubota K, Ueda K, Kawase Y, Yabe K, Yokoyama M, Shimada K. Noguchi T, et al. Among authors: takano r. Bioorg Med Chem Lett. 2021 Mar 15;36:127790. doi: 10.1016/j.bmcl.2021.127790. Epub 2021 Jan 14. Bioorg Med Chem Lett. 2021. PMID: 33454387
251 results