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Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists.
Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Toda N. Takano R, et al. Among authors: toda n. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2949-53. doi: 10.1016/j.bmcl.2014.04.065. Epub 2014 Apr 26. Bioorg Med Chem Lett. 2014. PMID: 24835985
Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists.
Nakashima R, Yano T, Ogawa J, Tanaka N, Toda N, Yoshida M, Takano R, Inoue M, Honda T, Kume S, Matsumoto K. Nakashima R, et al. Among authors: toda n. Eur J Pharmacol. 2014 Aug 15;737:194-201. doi: 10.1016/j.ejphar.2014.05.014. Epub 2014 May 22. Eur J Pharmacol. 2014. PMID: 24858371
Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.
Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Hirouchi M, Yoneyama T, Ito S, Toda N. Takano R, et al. Among authors: toda n. ACS Med Chem Lett. 2015 Jan 13;6(3):266-70. doi: 10.1021/ml500391n. eCollection 2015 Mar 12. ACS Med Chem Lett. 2015. PMID: 25815144 Free PMC article.
Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.
Toda N, Hao X, Ogawa Y, Oda K, Yu M, Fu Z, Chen Y, Kim Y, Lizarzaburu M, Lively S, Lawlis S, Murakoshi M, Nara F, Watanabe N, Reagan JD, Tian H, Fu A, Motani A, Liu Q, Lin YJ, Zhuang R, Xiong Y, Fan P, Medina J, Li L, Izumi M, Okuyama R, Shibuya S. Toda N, et al. ACS Med Chem Lett. 2013 Jun 17;4(8):790-4. doi: 10.1021/ml400186z. eCollection 2013 Aug 8. ACS Med Chem Lett. 2013. PMID: 24900747 Free PMC article.
Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease.
Abe Y, Aoyagi A, Hara T, Abe K, Yamazaki R, Kumagae Y, Naruto S, Koyama K, Marumoto S, Tago K, Toda N, Takami K, Yamada N, Ori M, Kogen H, Kaneko T. Abe Y, et al. Among authors: toda n. J Pharmacol Sci. 2003 Sep;93(1):95-105. doi: 10.1254/jphs.93.95. J Pharmacol Sci. 2003. PMID: 14501158 Free article.
754 results