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Healthy volunteers in first-in-human oncology drug development for small molecules.
de Las Heras B, Bouyoucef-Cherchalli D, Reeve L, Reichl A, Mandarino D, Flach S, Vidal L, van Brummelen EMJ, Steeghs N. de Las Heras B, et al. Among authors: mandarino d. Br J Clin Pharmacol. 2022 Feb;88(4):1773-1784. doi: 10.1111/bcp.15092. Epub 2021 Oct 19. Br J Clin Pharmacol. 2022. PMID: 34558113 Free PMC article. Review.
Pharmacokinetic Assessment of Drug-Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults.
Groll AH, Desai A, Han D, Howieson C, Kato K, Akhtar S, Kowalski D, Lademacher C, Lewis W, Pearlman H, Mandarino D, Yamazaki T, Townsend R. Groll AH, et al. Among authors: mandarino d. Clin Pharmacol Drug Dev. 2017 Jan;6(1):76-85. doi: 10.1002/cpdd.284. Epub 2016 Jul 25. Clin Pharmacol Drug Dev. 2017. PMID: 27273343 Free PMC article. Clinical Trial.
Mass balance, metabolite profile, and in vitro-in vivo comparison of clearance pathways of deleobuvir, a hepatitis C virus polymerase inhibitor.
Chen LZ, Sabo JP, Philip E, Rowland L, Mao Y, Latli B, Ramsden D, Mandarino DA, Sane RS. Chen LZ, et al. Among authors: mandarino da. Antimicrob Agents Chemother. 2015 Jan;59(1):25-37. doi: 10.1128/AAC.03861-14. Epub 2014 Oct 13. Antimicrob Agents Chemother. 2015. PMID: 25313217 Free PMC article. Clinical Trial.