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Page 1
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Dominy JE Jr, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. Dominy JE Jr, et al. Among authors: clish cb. Mol Cell. 2012 Dec 28;48(6):900-13. doi: 10.1016/j.molcel.2012.09.030. Epub 2012 Nov 8. Mol Cell. 2012. PMID: 23142079 Free PMC article.
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.
Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC. Jeong SM, et al. Among authors: clish cb. Cancer Cell. 2013 Apr 15;23(4):450-63. doi: 10.1016/j.ccr.2013.02.024. Epub 2013 Apr 4. Cancer Cell. 2013. PMID: 23562301 Free PMC article.
A combined epidemiologic and metabolomic approach improves CKD prediction.
Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten RE. Rhee EP, et al. Among authors: clish cb. J Am Soc Nephrol. 2013 Jul;24(8):1330-8. doi: 10.1681/ASN.2012101006. Epub 2013 May 16. J Am Soc Nephrol. 2013. PMID: 23687356 Free PMC article.
A genome-wide association study of the human metabolome in a community-based cohort.
Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish C, Yeh JR, Wang TJ, Gerszten RE. Rhee EP, et al. Cell Metab. 2013 Jul 2;18(1):130-43. doi: 10.1016/j.cmet.2013.06.013. Cell Metab. 2013. PMID: 23823483 Free PMC article.
2-Aminoadipic acid is a biomarker for diabetes risk.
Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE. Wang TJ, et al. Among authors: clish cb. J Clin Invest. 2013 Oct;123(10):4309-17. doi: 10.1172/JCI64801. Epub 2013 Sep 16. J Clin Invest. 2013. PMID: 24091325 Free PMC article.
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.
Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM. Mayers JR, et al. Among authors: clish cb. Nat Med. 2014 Oct;20(10):1193-1198. doi: 10.1038/nm.3686. Epub 2014 Sep 28. Nat Med. 2014. PMID: 25261994 Free PMC article.
507 results