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Page 1
Pyrazinyl-Substituted Aminoazoles as Covalent Inhibitors of Thrombin: Synthesis, Structure, and Anticoagulant Properties.
Imberg L, Siutkina AI, Erbacher C, Schmidt J, Broekmans DF, Ovsepyan RA, Daniliuc CG, Gonçalves de Oliveira E, Serafim MSM, O'Donoghue AJ, Pillaiyar T, Panteleev MA, Poso A, Kalinina SA, Bermúdez M, Nekipelov K, Bendas G, Karst U, Kalinin DV. Imberg L, et al. Among authors: o donoghue aj. ACS Pharmacol Transl Sci. 2024 Dec 11;8(1):146-172. doi: 10.1021/acsptsci.4c00515. eCollection 2025 Jan 10. ACS Pharmacol Transl Sci. 2024. PMID: 39816788
Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity.
Flury P, Krüger N, Sylvester K, Breidenbach J, Al Hamwi G, Qiao J, Chen Y, Rocha C, Serafim MSM, Barbosa da Silva E, Pöhlmann S, Poso A, Kronenberger T, Rox K, O'Donoghue AJ, Yang S, Sträter N, Gütschow M, Laufer SA, Müller CE, Pillaiyar T. Flury P, et al. Among authors: o donoghue aj. J Med Chem. 2025 Jan 15. doi: 10.1021/acs.jmedchem.4c02254. Online ahead of print. J Med Chem. 2025. PMID: 39813204
A multiplex method for rapidly identifying viral protease inhibitors.
Hong SJ, Resnick SJ, Iketani S, Cha JW, Albert BA, Fazekas CT, Chang CW, Liu H, Dagan S, Abagyan MR, Fajtová P, Culbertson B, Brace B, Reddem ER, Forouhar F, Glickman JF, Balkovec JM, Stockwell BR, Shapiro L, O'Donoghue AJ, Sabo Y, Freundlich JS, Ho DD, Chavez A. Hong SJ, et al. Among authors: o donoghue aj. Mol Syst Biol. 2025 Jan 6. doi: 10.1038/s44320-024-00082-1. Online ahead of print. Mol Syst Biol. 2025. PMID: 39762652 Free article.
Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship and In Vivo Efficacy.
Liu LJ, Francisco KR, Sun YU, Serafim MSM, Amarasinghe DK, Teixeira TR, Lucero B, Kronenberger T, Elsayed W, Elwakeel H, Al-Hindy M, Almaliti J, Gerwick WH, O'Donoghue AJ, Caffrey CR. Liu LJ, et al. Among authors: o donoghue aj. ACS Infect Dis. 2024 Dec 13;10(12):4182-4193. doi: 10.1021/acsinfecdis.4c00441. Epub 2024 Nov 26. ACS Infect Dis. 2024. PMID: 39589805 Free PMC article.
Evaluating Antimalarial Proteasome Inhibitors for Efficacy in Babesia Blood Stage Cultures.
Robbertse L, Fajtová P, Šnebergerová P, Jalovecká M, Levytska V, Barbosa da Silva E, Sharma V, Pachl P, Almaliti J, Al-Hindy M, Gerwick WH, Bouřa E, O'Donoghue AJ, Sojka D. Robbertse L, et al. Among authors: o donoghue aj. ACS Omega. 2024 Oct 28;9(45):44989-44999. doi: 10.1021/acsomega.4c04564. eCollection 2024 Nov 12. ACS Omega. 2024. PMID: 39554424 Free PMC article.
Development of an Antiviral Medicinal Plant and Natural Product Database (avMpNp Database) from Biodiversity.
Quadros de Azevedo D, Vinícius Viera Nóia J, Ribeiro YCM, Alves Dos Reis R, Ribeiro PHO, Almeida Moura G, Mendes P, Barbosa de Souza AB, Carpini Mermejo S, Serafim MSM, Fernandes THM, O'Donoghue AJ, Campos ACFA, Campos SVA, Gonçalves Maltarollo V, Oliveira Castilho R. Quadros de Azevedo D, et al. Among authors: o donoghue aj. Chem Biodivers. 2024 Dec;21(12):e202400285. doi: 10.1002/cbdv.202400285. Epub 2024 Nov 15. Chem Biodivers. 2024. PMID: 39546588
266 results