Clausen RP - Search Results

1

Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).

Al-Khawaja A, Petersen JG, Damgaard M, Jensen MH, Vogensen SB, Lie ME, Kragholm B, Bräuner-Osborne H, Clausen RP, Frølund B, Wellendorph P. Al-Khawaja A, et al. Among authors: clausen rp. Neurochem Res. 2014 Oct;39(10):1988-96. doi: 10.1007/s11064-014-1336-9. Epub 2014 May 23. Neurochem Res. 2014. PMID: 24852577

2

Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.

Clausen RP, Bräuner-Osborne H, Greenwood JR, Hermit MB, Stensbøl TB, Nielsen B, Krogsgaard-Larsen P. Clausen RP, et al. J Med Chem. 2002 Sep 12;45(19):4240-5. doi: 10.1021/jm020122x. J Med Chem. 2002. PMID: 12213064

3

A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

Vogensen SB, Greenwood JR, Varming AR, Brehm L, Pickering DS, Nielsen B, Liljefors T, Clausen RP, Johansen TN, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: clausen rp. Org Biomol Chem. 2004 Jan 21;2(2):206-13. doi: 10.1039/b310450h. Epub 2003 Nov 24. Org Biomol Chem. 2004. PMID: 14737644

4

The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

Clausen RP, Hansen KB, Calí P, Nielsen B, Greenwood JR, Begtrup M, Egebjerg J, Bräuner-Osborne H. Clausen RP, et al. Eur J Pharmacol. 2004 Sep 19;499(1-2):35-44. doi: 10.1016/j.ejphar.2004.07.049. Eur J Pharmacol. 2004. PMID: 15363949

5

First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.

White HS, Watson WP, Hansen SL, Slough S, Perregaard J, Sarup A, Bolvig T, Petersen G, Larsson OM, Clausen RP, Frølund B, Falch E, Krogsgaard-Larsen P, Schousboe A. White HS, et al. Among authors: clausen rp. J Pharmacol Exp Ther. 2005 Feb;312(2):866-74. doi: 10.1124/jpet.104.068825. Epub 2004 Nov 18. J Pharmacol Exp Ther. 2005. PMID: 15550575

6

Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.

Clausen RP, Moltzen EK, Perregaard J, Lenz SM, Sanchez C, Falch E, Frølund B, Bolvig T, Sarup A, Larsson OM, Schousboe A, Krogsgaard-Larsen P. Clausen RP, et al. Bioorg Med Chem. 2005 Feb 1;13(3):895-908. doi: 10.1016/j.bmc.2004.10.029. Bioorg Med Chem. 2005. PMID: 15653355

7

Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.

Vogensen SB, Clausen RP, Greenwood JR, Johansen TN, Pickering DS, Nielsen B, Ebert B, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: clausen rp. J Med Chem. 2005 May 5;48(9):3438-42. doi: 10.1021/jm050014l. J Med Chem. 2005. PMID: 15857151

8

Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.

Wellendorph P, Høg S, Greenwood JR, de Lichtenberg A, Nielsen B, Frølund B, Brehm L, Clausen RP, Bräuner-Osborne H. Wellendorph P, et al. Among authors: clausen rp. J Pharmacol Exp Ther. 2005 Oct;315(1):346-51. doi: 10.1124/jpet.105.090472. Epub 2005 Jul 12. J Pharmacol Exp Ther. 2005. PMID: 16014570

9

Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis.

Hansen KB, Clausen RP, Bjerrum EJ, Bechmann C, Greenwood JR, Christensen C, Kristensen JL, Egebjerg J, Bräuner-Osborne H. Hansen KB, et al. Among authors: clausen rp. Mol Pharmacol. 2005 Dec;68(6):1510-23. doi: 10.1124/mol.105.014795. Epub 2005 Aug 30. Mol Pharmacol. 2005. PMID: 16131614

10

A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.

Clausen RP, Frølund B, Larsson OM, Schousboe A, Krogsgaard-Larsen P, White HS. Clausen RP, et al. Neurochem Int. 2006 May-Jun;48(6-7):637-42. doi: 10.1016/j.neuint.2005.12.031. Epub 2006 Mar 3. Neurochem Int. 2006. PMID: 16517017 Review.

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