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The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations.
Sjögren E, Lennernäs H, Andersson TB, Gråsjö J, Bredberg U. Sjögren E, et al. Among authors: lennernas h. Drug Metab Dispos. 2009 Jan;37(1):47-58. doi: 10.1124/dmd.108.021477. Epub 2008 Sep 29. Drug Metab Dispos. 2009. PMID: 18824525
Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.
Arvidsson B, Allard E, Sjögren E, Lennernäs H, Sjöberg PJ, Bergquist J. Arvidsson B, et al. Among authors: lennernas h. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):291-7. doi: 10.1016/j.jchromb.2008.12.017. Epub 2008 Dec 11. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19117807
260 results