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Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.
Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP. Thomas JB, et al. Among authors: sarret p. J Med Chem. 2014 Jun 26;57(12):5318-32. doi: 10.1021/jm5003843. Epub 2014 Jun 5. J Med Chem. 2014. PMID: 24856674 Free PMC article.
Altered morphine-induced analgesia in neurotensin type 1 receptor null mice.
Roussy G, Beaudry H, Lafrance M, Belleville K, Beaudet N, Wada K, Gendron L, Sarret P. Roussy G, et al. Among authors: sarret p. Neuroscience. 2010 Nov 10;170(4):1286-94. doi: 10.1016/j.neuroscience.2010.08.016. Epub 2010 Aug 18. Neuroscience. 2010. PMID: 20727387 Free PMC article.
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.
Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P. Demeule M, et al. Among authors: sarret p. J Clin Invest. 2014 Mar;124(3):1199-213. doi: 10.1172/JCI70647. Epub 2014 Feb 17. J Clin Invest. 2014. PMID: 24531547 Free PMC article.
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.
Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP. Thomas JB, et al. Among authors: sarret p. J Med Chem. 2014 Sep 11;57(17):7472-7. doi: 10.1021/jm500857r. Epub 2014 Aug 26. J Med Chem. 2014. PMID: 25157640 Free PMC article.
150 results