Melacini G - Search Results

1

A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.

Akimoto M, Zhang Z, Boulton S, Selvaratnam R, VanSchouwen B, Gloyd M, Accili EA, Lange OF, Melacini G. Akimoto M, et al. Among authors: melacini g. J Biol Chem. 2014 Aug 8;289(32):22205-20. doi: 10.1074/jbc.M114.572164. Epub 2014 May 30. J Biol Chem. 2014. PMID: 24878962 Free PMC article.

2

A model for agonism and antagonism in an ancient and ubiquitous cAMP-binding domain.

Das R, Melacini G. Das R, et al. Among authors: melacini g. J Biol Chem. 2007 Jan 5;282(1):581-93. doi: 10.1074/jbc.M607706200. Epub 2006 Oct 30. J Biol Chem. 2007. PMID: 17074757 Free article.

3

cAMP activation of PKA defines an ancient signaling mechanism.

Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G. Das R, et al. Among authors: melacini g. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):93-8. doi: 10.1073/pnas.0609033103. Epub 2006 Dec 20. Proc Natl Acad Sci U S A. 2007. PMID: 17182741 Free PMC article.

4

Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP.

Das R, Mazhab-Jafari MT, Chowdhury S, SilDas S, Selvaratnam R, Melacini G. Das R, et al. Among authors: melacini g. J Biol Chem. 2008 Jul 11;283(28):19691-703. doi: 10.1074/jbc.M802164200. Epub 2008 Apr 14. J Biol Chem. 2008. PMID: 18411261 Free article.

5

Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

Das R, Chowdhury S, Mazhab-Jafari MT, Sildas S, Selvaratnam R, Melacini G. Das R, et al. Among authors: melacini g. J Biol Chem. 2009 Aug 28;284(35):23682-96. doi: 10.1074/jbc.M109.011700. Epub 2009 Apr 29. J Biol Chem. 2009. PMID: 19403523 Free PMC article.

6

Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations.

McNicholl ET, Das R, SilDas S, Taylor SS, Melacini G. McNicholl ET, et al. Among authors: melacini g. J Biol Chem. 2010 May 14;285(20):15523-15537. doi: 10.1074/jbc.M110.105783. Epub 2010 Mar 4. J Biol Chem. 2010. PMID: 20202931 Free PMC article.

7

Mapping allostery through the covariance analysis of NMR chemical shifts.

Selvaratnam R, Chowdhury S, VanSchouwen B, Melacini G. Selvaratnam R, et al. Among authors: melacini g. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6133-8. doi: 10.1073/pnas.1017311108. Epub 2011 Mar 28. Proc Natl Acad Sci U S A. 2011. PMID: 21444788 Free PMC article.

8

Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC).

VanSchouwen B, Selvaratnam R, Fogolari F, Melacini G. VanSchouwen B, et al. Among authors: melacini g. J Biol Chem. 2011 Dec 9;286(49):42655-42669. doi: 10.1074/jbc.M111.277723. Epub 2011 Aug 26. J Biol Chem. 2011. PMID: 21873431 Free PMC article.

9

cAMP-dependent allostery and dynamics in Epac: an NMR view.

Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G. Selvaratnam R, et al. Among authors: melacini g. Biochem Soc Trans. 2012 Feb;40(1):219-23. doi: 10.1042/BST20110628. Biochem Soc Trans. 2012. PMID: 22260694 Review.

10

The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.

Selvaratnam R, VanSchouwen B, Fogolari F, Mazhab-Jafari MT, Das R, Melacini G. Selvaratnam R, et al. Among authors: melacini g. Biophys J. 2012 Feb 8;102(3):630-9. doi: 10.1016/j.bpj.2011.12.030. Epub 2012 Feb 7. Biophys J. 2012. PMID: 22325287 Free PMC article.

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