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Page 1
Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.
Rooney L, Vidal A, D'Souza AM, Devereux N, Masick B, Boissel V, West R, Head V, Stringer R, Lao J, Petrus MJ, Patapoutian A, Nash M, Stoakley N, Panesar M, Verkuyl JM, Schumacher AM, Petrassi HM, Tully DC. Rooney L, et al. Among authors: petrus mj. J Med Chem. 2014 Jun 26;57(12):5129-40. doi: 10.1021/jm401986p. Epub 2014 Jun 13. J Med Chem. 2014. PMID: 24884675
Zinc activates damage-sensing TRPA1 ion channels.
Hu H, Bandell M, Petrus MJ, Zhu MX, Patapoutian A. Hu H, et al. Among authors: petrus mj. Nat Chem Biol. 2009 Mar;5(3):183-90. doi: 10.1038/nchembio.146. Epub 2009 Feb 8. Nat Chem Biol. 2009. PMID: 19202543 Free PMC article.
Opposite thermosensor in fruitfly and mouse.
Viswanath V, Story GM, Peier AM, Petrus MJ, Lee VM, Hwang SW, Patapoutian A, Jegla T. Viswanath V, et al. Among authors: petrus mj. Nature. 2003 Jun 19;423(6942):822-3. doi: 10.1038/423822a. Nature. 2003. PMID: 12815418 No abstract available.
An ion channel essential for sensing chemical damage.
Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A. Macpherson LJ, et al. Among authors: petrus mj. J Neurosci. 2007 Oct 17;27(42):11412-5. doi: 10.1523/JNEUROSCI.3600-07.2007. J Neurosci. 2007. PMID: 17942735 Free PMC article.
29 results