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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. Zhang X, et al. Among authors: raghavan s. Bioorg Med Chem. 2014 Jul 15;22(14):3753-72. doi: 10.1016/j.bmc.2014.04.049. Epub 2014 May 14. Bioorg Med Chem. 2014. PMID: 24890652 Free PMC article.
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.
Gangjee A, Zaware N, Devambatla RK, Raghavan S, Westbrook CD, Dybdal-Hargreaves NF, Hamel E, Mooberry SL. Gangjee A, et al. Among authors: raghavan s. Bioorg Med Chem. 2013 Feb 15;21(4):891-902. doi: 10.1016/j.bmc.2012.12.010. Epub 2012 Dec 20. Bioorg Med Chem. 2013. PMID: 23332369 Free PMC article.
Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Gangjee A, Zaware N, Raghavan S, Disch BC, Thorpe JE, Bastian A, Ihnat MA. Gangjee A, et al. Among authors: raghavan s. Bioorg Med Chem. 2013 Apr 1;21(7):1857-64. doi: 10.1016/j.bmc.2013.01.040. Epub 2013 Jan 31. Bioorg Med Chem. 2013. PMID: 23434139 Free PMC article.
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
Gangjee A, Zhao Y, Raghavan S, Rohena CC, Mooberry SL, Hamel E. Gangjee A, et al. Among authors: raghavan s. J Med Chem. 2013 Sep 12;56(17):6829-44. doi: 10.1021/jm400639z. Epub 2013 Aug 29. J Med Chem. 2013. PMID: 23895532 Free PMC article.
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.
Wang Y, Mitchell-Ryan S, Raghavan S, George C, Orr S, Hou Z, Matherly LH, Gangjee A. Wang Y, et al. Among authors: raghavan s. J Med Chem. 2015 Feb 12;58(3):1479-93. doi: 10.1021/jm501787c. Epub 2015 Feb 2. J Med Chem. 2015. PMID: 25602637 Free PMC article.
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. Zhang X, et al. Among authors: raghavan s. Bioorg Med Chem. 2015 May 15;23(10):2408-23. doi: 10.1016/j.bmc.2015.03.061. Epub 2015 Mar 30. Bioorg Med Chem. 2015. PMID: 25882519 Free PMC article.
1,163 results