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Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists.
Jin J, Morales-Ramos A, Eidam P, Mecom J, Li Y, Brooks C, Hilfiker M, Zhang D, Wang N, Shi D, Tseng PS, Wheless K, Budzik B, Evans K, Jaworski JP, Jugus J, Leon L, Wu C, Pullen M, Karamshi B, Rao P, Ward E, Laping N, Evans C, Leach C, Holt D, Su X, Morrow D, Fries H, Thorneloe K, Edwards R. Jin J, et al. Among authors: su x. ACS Med Chem Lett. 2010 May 14;1(7):316-20. doi: 10.1021/ml100077x. eCollection 2010 Oct 14. ACS Med Chem Lett. 2010. PMID: 24900213 Free PMC article.
An excitatory role for peripheral EP3 receptors in bladder afferent function.
Su X, Lashinger ES, Leon LA, Hoffman BE, Hieble JP, Gardner SD, Fries HE, Edwards RM, Li J, Laping NJ. Su X, et al. Am J Physiol Renal Physiol. 2008 Aug;295(2):F585-94. doi: 10.1152/ajprenal.90273.2008. Epub 2008 Jun 18. Am J Physiol Renal Physiol. 2008. PMID: 18562635 Free article.
Effects of the beta 3-adrenergic receptor agonist disodium 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316243) on bladder micturition reflex in spontaneously hypertensive rats.
Leon LA, Hoffman BE, Gardner SD, Laping NJ, Evans C, Lashinger ES, Su X. Leon LA, et al. Among authors: su x. J Pharmacol Exp Ther. 2008 Jul;326(1):178-85. doi: 10.1124/jpet.108.138651. Epub 2008 Apr 15. J Pharmacol Exp Ther. 2008. PMID: 18413856
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