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Page 1
Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators.
Qin J, Zhou W, Huang X, Dhondi P, Palani A, Aslanian R, Zhu Z, Greenlee W, Cohen-Williams M, Jones N, Hyde L, Zhang L. Qin J, et al. Among authors: zhu z. ACS Med Chem Lett. 2011 Mar 29;2(6):471-6. doi: 10.1021/ml2000438. eCollection 2011 Jun 9. ACS Med Chem Lett. 2011. PMID: 24900332 Free PMC article.
Iminoheterocycles as gamma-secretase modulators.
Caldwell JP, Bennett CE, McCracken TM, Mazzola RD, Bara T, Buevich A, Burnett DA, Chu I, Cohen-Williams M, Josein H, Hyde L, Lee J, McKittrick B, Song L, Terracina G, Voigt J, Zhang L, Zhu Z. Caldwell JP, et al. Among authors: zhu z. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5380-4. doi: 10.1016/j.bmcl.2010.07.121. Epub 2010 Aug 1. Bioorg Med Chem Lett. 2010. PMID: 20724152
Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators.
Qin J, Dhondi P, Huang X, Mandal M, Zhao Z, Pissarnitski D, Zhou W, Aslanian R, Zhu Z, Greenlee W, Clader J, Zhang L, Cohen-Williams M, Jones N, Hyde L, Palani A. Qin J, et al. Among authors: zhu z. Bioorg Med Chem Lett. 2011 Jan 15;21(2):664-9. doi: 10.1016/j.bmcl.2010.12.012. Epub 2010 Dec 13. Bioorg Med Chem Lett. 2011. PMID: 21195610
Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.
Sun ZY, Asberom T, Bara T, Bennett C, Burnett D, Chu I, Clader J, Cohen-Williams M, Cole D, Czarniecki M, Durkin J, Gallo G, Greenlee W, Josien H, Huang X, Hyde L, Jones N, Kazakevich I, Li H, Liu X, Lee J, Maccoss M, Mandal MB, McCracken T, Nomeir A, Mazzola R, Palani A, Parker EM, Pissarnitski DA, Qin J, Song L, Terracina G, Vicarel M, Voigt J, Xu R, Zhang L, Zhang Q, Zhao Z, Zhu X, Zhu Z. Sun ZY, et al. Among authors: zhu x, zhu z. J Med Chem. 2012 Jan 12;55(1):489-502. doi: 10.1021/jm201407j. Epub 2011 Dec 8. J Med Chem. 2012. PMID: 22098494
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Li H, Qin J, Dhondi P, Zhou W, Vicarel M, Bara T, Cole D, Josien H, Pissarnitski D, Zhu Z, Palani A, Aslanian R, Clader J, Czarniecki M, Greenlee W, Cohen-Williams M, Hyde L, Song L, Zhang L, Chu I, Huang X. Li H, et al. Among authors: zhu z. Bioorg Med Chem Lett. 2013 Jan 15;23(2):466-71. doi: 10.1016/j.bmcl.2012.11.055. Epub 2012 Nov 29. Bioorg Med Chem Lett. 2013. PMID: 23253441
The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators.
Huang X, Aslanian R, Zhou W, Zhu X, Qin J, Greenlee W, Zhu Z, Zhang L, Hyde L, Chu I, Cohen-Williams M, Palani A. Huang X, et al. Among authors: zhu x, zhu z. ACS Med Chem Lett. 2010 May 24;1(4):184-7. doi: 10.1021/ml1000799. eCollection 2010 Jul 8. ACS Med Chem Lett. 2010. PMID: 24900193 Free PMC article.
Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.
Huang X, Zhou W, Liu X, Li H, Sun G, Mandal M, Vicarel M, Zhu X, Bennett C, McCraken T, Pissarnitski D, Zhao Z, Cole D, Gallo G, Zhu Z, Palani A, Aslanian R, Clader J, Czarniecki M, Greenlee W, Burnett D, Cohen-Williams M, Hyde L, Song L, Zhang L, Chu I, Buevich A. Huang X, et al. Among authors: zhu x, zhu z. ACS Med Chem Lett. 2012 Sep 4;3(11):931-5. doi: 10.1021/ml300209g. eCollection 2012 Nov 8. ACS Med Chem Lett. 2012. PMID: 24900409 Free PMC article.
Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators.
Zhao Z, Pissarnitski DA, Huang X, Palani A, Zhu Z, Greenlee WJ, Hyde LA, Song L, Terracina G, Zhang L, Parker EM. Zhao Z, et al. Among authors: zhu z. ACS Med Chem Lett. 2017 Sep 19;8(10):1002-1006. doi: 10.1021/acsmedchemlett.7b00178. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057041 Free PMC article.
Generation of Leads for γ-Secretase Modulation.
Mandal M, Buevich A, Caldwell JP, Hyde L, Huang X, Liu X, McKittrick B, Mazzola RD, Pissarnitski D, Palani A, Zhang L, Parker E, Xiao L, Rindgen D, Zhu Z. Mandal M, et al. Among authors: zhu z. J Med Chem. 2020 Aug 13;63(15):8216-8230. doi: 10.1021/acs.jmedchem.0c00446. Epub 2020 Aug 4. J Med Chem. 2020. PMID: 32786237
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