Xia G - Search Results

1

Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors.

Yu J, Liu H, Xia G, Liu L, Xu Z, Chen Q, Ma C, Sun X, Xu J, Li H, Li P, Shi Y, Xiong B, Liu X, Shen J. Yu J, et al. Among authors: xia g. ACS Med Chem Lett. 2012 Sep 20;3(10):793-8. doi: 10.1021/ml300144n. eCollection 2012 Oct 11. ACS Med Chem Lett. 2012. PMID: 24900382 Free PMC article.

2

Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives.

Xia G, Li J, Peng A, Lai S, Zhang S, Shen J, Liu Z, Chen X, Ji R. Xia G, et al. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2790-4. doi: 10.1016/j.bmcl.2005.03.102. Bioorg Med Chem Lett. 2005. PMID: 15878277

3

(S)-tert-Butyl 3-(3-phenyl-1,2,4-oxa-diazol-5-yl)piperidine-1-carboxyl-ate.

Liu L, Xia G, Liu X, Xie J, Shen J. Liu L, et al. Among authors: xia g. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 5;66(Pt 7):o1576. doi: 10.1107/S1600536810018714. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21587817 Free PMC article.

4

(2R,6S)-tert-Butyl 2-(benzhydryl-carbamo-yl)-6-methyl-morpholine-4-carboxyl-ate.

Wang H, Xia G, Liu X, Shen J. Wang H, et al. Among authors: xia g. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1437. doi: 10.1107/S1600536811017764. Epub 2011 May 20. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 21754815 Free PMC article.

5

Potent and novel 11β-HSD1 inhibitors identified from shape and docking based virtual screening.

Xia G, Xue M, Liu L, Yu J, Liu H, Li P, Wang J, Li Y, Xiong B, Shen J. Xia G, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5739-44. doi: 10.1016/j.bmcl.2011.08.019. Epub 2011 Aug 8. Bioorg Med Chem Lett. 2011. PMID: 21873057

6

Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1.

Xia G, Liu L, Xue M, Liu H, Yu J, Li P, Chen Q, Xiong B, Liu X, Shen J. Xia G, et al. Mol Cell Endocrinol. 2012 Jul 6;358(1):46-52. doi: 10.1016/j.mce.2012.02.017. Epub 2012 Mar 3. Mol Cell Endocrinol. 2012. PMID: 22410288

7

Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors.

Xia G, You X, Liu L, Liu H, Wang J, Shi Y, Li P, Xiong B, Liu X, Shen J. Xia G, et al. Eur J Med Chem. 2013 Apr;62:1-10. doi: 10.1016/j.ejmech.2012.12.059. Epub 2013 Jan 10. Eur J Med Chem. 2013. PMID: 23353742

8

Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Xia G, Liu L, Liu H, Yu J, Xu Z, Chen Q, Ma C, Li P, Xiong B, Liu X, Shen J. Xia G, et al. ChemMedChem. 2013 Apr;8(4):577-81. doi: 10.1002/cmdc.201300022. Epub 2013 Mar 7. ChemMedChem. 2013. PMID: 23471829

9

Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR.

Wu J, Chen W, Xia G, Zhang J, Shao J, Tan B, Zhang C, Yu W, Weng Q, Liu H, Hu M, Deng H, Hao Y, Shen J, Yu Y. Wu J, et al. Among authors: xia g. ACS Med Chem Lett. 2013 Aug 6;4(10):974-8. doi: 10.1021/ml4002437. eCollection 2013 Oct 10. ACS Med Chem Lett. 2013. PMID: 24900594 Free PMC article.

10

A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles.

Xia G, Chen W, Zhang J, Shao J, Zhang Y, Huang W, Zhang L, Qi W, Sun X, Li B, Xiang Z, Ma C, Xu J, Deng H, Li Y, Li P, Miao H, Han J, Liu Y, Shen J, Yu Y. Xia G, et al. J Med Chem. 2014 Dec 11;57(23):9889-900. doi: 10.1021/jm5014659. Epub 2014 Dec 1. J Med Chem. 2014. PMID: 25409491

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