Hixon MS - Search Results

1

A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.

Iwata H, Oki H, Okada K, Takagi T, Tawada M, Miyazaki Y, Imamura S, Hori A, Lawson JD, Hixon MS, Kimura H, Miki H. Iwata H, et al. Among authors: hixon ms. ACS Med Chem Lett. 2012 Feb 28;3(4):342-6. doi: 10.1021/ml3000403. eCollection 2012 Apr 12. ACS Med Chem Lett. 2012. PMID: 24900475 Free PMC article.

2

Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism.

Iwata H, Imamura S, Hori A, Hixon MS, Kimura H, Miki H. Iwata H, et al. Among authors: hixon ms. Biochemistry. 2011 Feb 8;50(5):738-51. doi: 10.1021/bi101777f. Epub 2011 Jan 10. Biochemistry. 2011. PMID: 21182308

3

Biochemical characterization of a novel type-II VEGFR2 kinase inhibitor: comparison of binding to non-phosphorylated and phosphorylated VEGFR2.

Iwata H, Imamura S, Hori A, Hixon MS, Kimura H, Miki H. Iwata H, et al. Among authors: hixon ms. Bioorg Med Chem. 2011 Sep 15;19(18):5342-51. doi: 10.1016/j.bmc.2011.08.002. Epub 2011 Aug 6. Bioorg Med Chem. 2011. PMID: 21885287

4

A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).

Lanier M, Ambrus G, Cole DC, Davenport R, Ellery J, Fosbeary R, Jennings AJ, Kadotani A, Kamada Y, Kamran R, Matsumoto S, Mizukami A, Okubo S, Okada K, Saikatendu K, Walsh L, Wu H, Hixon MS. Lanier M, et al. Among authors: hixon ms. J Med Chem. 2014 Jun 26;57(12):5459-63. doi: 10.1021/jm500475k. Epub 2014 Jun 4. J Med Chem. 2014. PMID: 24847974

5

A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.

Sameshima T, Miyahisa I, Homma M, Aikawa K, Hixon MS, Matsui J. Sameshima T, et al. Among authors: hixon ms. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5836-5839. doi: 10.1016/j.bmcl.2014.09.073. Epub 2014 Oct 2. Bioorg Med Chem Lett. 2014. PMID: 25452002

6

Fragment-based drug discovery of potent and selective MKK3/6 inhibitors.

Adams M, Kobayashi T, Lawson JD, Saitoh M, Shimokawa K, Bigi SV, Hixon MS, Smith CR, Tatamiya T, Goto M, Russo J, Grimshaw CE, Swann S. Adams M, et al. Among authors: hixon ms. Bioorg Med Chem Lett. 2016 Feb 1;26(3):1086-1089. doi: 10.1016/j.bmcl.2015.11.054. Epub 2015 Nov 17. Bioorg Med Chem Lett. 2016. PMID: 26704264

7

Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors.

Wang H, Lawson JD, Scorah N, Kamran R, Hixon MS, Atienza J, Dougan DR, Sabat M. Wang H, et al. Among authors: hixon ms. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4334-9. doi: 10.1016/j.bmcl.2016.07.030. Epub 2016 Jul 16. Bioorg Med Chem Lett. 2016. PMID: 27460209

8

T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time.

Miyahisa I, Suzuki H, Mizukami A, Tanaka Y, Ono M, Hixon MS, Matsui J. Miyahisa I, et al. Among authors: hixon ms. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72. doi: 10.1021/acsmedchemlett.6b00241. eCollection 2016 Sep 8. ACS Med Chem Lett. 2016. PMID: 27660693 Free PMC article.

9

MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody.

Farrell PJ, Matuszkiewicz J, Balakrishna D, Pandya S, Hixon MS, Kamran R, Chu S, Lawson JD, Okada K, Hori A, Mizutani A, Iwata H, de Jong R, Hibner B, Vincent P. Farrell PJ, et al. Among authors: hixon ms. Mol Cancer Ther. 2017 Jul;16(7):1269-1278. doi: 10.1158/1535-7163.MCT-16-0771. Epub 2017 Mar 24. Mol Cancer Ther. 2017. PMID: 28341789

10

Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors.

Sabat M, Wang H, Scorah N, Lawson JD, Atienza J, Kamran R, Hixon MS, Dougan DR. Sabat M, et al. Among authors: hixon ms. Bioorg Med Chem Lett. 2017 May 1;27(9):1955-1961. doi: 10.1016/j.bmcl.2017.03.026. Epub 2017 Mar 14. Bioorg Med Chem Lett. 2017. PMID: 28359790

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