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Page 1
Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.
Brown DG, Bernstein PR, Wu Y, Urbanek RA, Becker CW, Throner SR, Dembofsky BT, Steelman GB, Lazor LA, Scott CW, Wood MW, Wesolowski SS, Nugiel DA, Koch S, Yu J, Pivonka DE, Li S, Thompson C, Zacco A, Elmore CS, Schroeder P, Liu J, Hurley CA, Ward S, Hunt HJ, Williams K, McLaughlin J, Hoesch V, Sydserff S, Maier D, Aharony D. Brown DG, et al. Among authors: steelman gb. ACS Med Chem Lett. 2012 Nov 12;4(1):46-51. doi: 10.1021/ml300262e. eCollection 2013 Jan 10. ACS Med Chem Lett. 2012. PMID: 24900562 Free PMC article.
Pyridazinoquinolinetriones as NMDA glycine-site antagonists with oral antinociceptive activity in a model of neuropathic pain.
Bare TM, Brown DG, Horchler CL, Murphy M, Urbanek RA, Alford V, Barlaam C, Dyroff MC, Empfield JB, Forst JM, Herzog KJ, Keith RA, Kirschner AS, Lee CM, Lewis J, McLaren FM, Neilson KL, Steelman GB, Trivedi S, Vacek EP, Xiao W. Bare TM, et al. Among authors: steelman gb. J Med Chem. 2007 Jun 28;50(13):3113-31. doi: 10.1021/jm060212s. Epub 2007 Jun 2. J Med Chem. 2007. PMID: 17542571
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists.
Brown DG, Urbanek RA, Bare TM, McLaren FM, Horchler CL, Murphy M, Steelman GB, Empfield JR, Forst JM, Herzog KJ, Xiao W, Dyroff MC, Lee CM, Trivedi S, Neilson KL, Keith RA. Brown DG, et al. Among authors: steelman gb. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3553-6. doi: 10.1016/s0960-894x(03)00750-9. Bioorg Med Chem Lett. 2003. PMID: 14505669
Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1.
Varnes JG, Xiong H, Forst JM, Holmquist CR, Ernst GE, Frietze W, Dembofsky B, Andisik DW, Palmer WE, Hinkley L, Steelman GB, Wilkins DE, Tian G, Jonak G, Potts WM, Wang X, Brugel TA, Alhambra C, Wood MW, Veale CA, Albert JS. Varnes JG, et al. Among authors: steelman gb. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1043-1049. doi: 10.1016/j.bmcl.2018.02.029. Epub 2018 Feb 14. Bioorg Med Chem Lett. 2018. PMID: 29486970
Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.
Veale CA, Bernstein PR, Bohnert CM, Brown FJ, Bryant C, Damewood JR Jr, Earley R, Feeney SW, Edwards PD, Gomes B, Hulsizer JM, Kosmider BJ, Krell RD, Moore G, Salcedo TW, Shaw A, Silberstein DS, Steelman GB, Stein M, Strimpler A, Thomas RM, Vacek EP, Williams JC, Wolanin DJ, Woolson S. Veale CA, et al. Among authors: steelman gb. J Med Chem. 1997 Sep 26;40(20):3173-81. doi: 10.1021/jm970250z. J Med Chem. 1997. PMID: 9379436
The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.
Veale CA, Alford VC, Aharony D, Banville DL, Bialecki RA, Brown FJ, Damewood JR Jr, Dantzman CL, Edwards PD, Jacobs RT, Mauger RC, Murphy MM, Palmer W, Pine KK, Rumsey WL, Garcia-Davenport LE, Shaw A, Steelman GB, Surian JM, Vacek EP. Veale CA, et al. Among authors: steelman gb. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1949-52. doi: 10.1016/s0960-894x(00)00387-5. Bioorg Med Chem Lett. 2000. PMID: 10987424
12 results