McGill MR - Search Results

1

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.

Xie Y, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, Jaeschke H. Xie Y, et al. Among authors: mcgill mr. Toxicol Appl Pharmacol. 2014 Sep 15;279(3):266-274. doi: 10.1016/j.taap.2014.05.010. Epub 2014 Jun 3. Toxicol Appl Pharmacol. 2014. PMID: 24905542 Free PMC article.

2

Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity.

Jaeschke H, Williams CD, McGill MR, Farhood A. Jaeschke H, et al. Among authors: mcgill mr. World J Gastroenterol. 2010 May 21;16(19):2448-50. doi: 10.3748/wjg.v16.i19.2448. World J Gastroenterol. 2010. PMID: 20480535 Free PMC article.

3

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

Jaeschke H, McGill MR, Williams CD, Ramachandran A. Jaeschke H, et al. Among authors: mcgill mr. Life Sci. 2011 Apr 25;88(17-18):737-45. doi: 10.1016/j.lfs.2011.01.025. Epub 2011 Feb 4. Life Sci. 2011. PMID: 21296090 Free PMC article. Review.

4

HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.

McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H. McGill MR, et al. Hepatology. 2011 Mar;53(3):974-82. doi: 10.1002/hep.24132. Epub 2011 Feb 11. Hepatology. 2011. PMID: 21319200 Free PMC article.

5

Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.

Jaeschke H, McGill MR, Ramachandran A. Jaeschke H, et al. Among authors: mcgill mr. Toxicol Sci. 2011 Jun;121(2):428-30; author reply 431-3. doi: 10.1093/toxsci/kfr053. Epub 2011 Mar 7. Toxicol Sci. 2011. PMID: 21385733 Free PMC article. No abstract available.

6

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.

Jaeschke H, McGill MR, Ramachandran A. Jaeschke H, et al. Among authors: mcgill mr. Drug Metab Rev. 2012 Feb;44(1):88-106. doi: 10.3109/03602532.2011.602688. Epub 2012 Jan 10. Drug Metab Rev. 2012. PMID: 22229890 Free PMC article. Review.

7

RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.

Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK. Antoine DJ, et al. Among authors: mcgill mr. J Hepatol. 2012 May;56(5):1070-1079. doi: 10.1016/j.jhep.2011.12.019. Epub 2012 Jan 17. J Hepatol. 2012. Retraction in: J Hepatol. 2020 Nov;73(5):1297. doi: 10.1016/j.jhep.2020.08.022 PMID: 22266604 Free PMC article. Retracted.

8

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H. McGill MR, et al. J Clin Invest. 2012 Apr;122(4):1574-83. doi: 10.1172/JCI59755. Epub 2012 Mar 1. J Clin Invest. 2012. PMID: 22378043 Free PMC article.

9

Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.

Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX. Ni HM, et al. Among authors: mcgill mr. Toxicol Sci. 2012 Jun;127(2):438-50. doi: 10.1093/toxsci/kfs133. Epub 2012 Apr 5. Toxicol Sci. 2012. PMID: 22491424 Free PMC article.

10

Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.

Aubert J, Begriche K, Delannoy M, Morel I, Pajaud J, Ribault C, Lepage S, McGill MR, Lucas-Clerc C, Turlin B, Robin MA, Jaeschke H, Fromenty B. Aubert J, et al. Among authors: mcgill mr. J Pharmacol Exp Ther. 2012 Sep;342(3):676-87. doi: 10.1124/jpet.112.193813. Epub 2012 May 30. J Pharmacol Exp Ther. 2012. PMID: 22647274

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