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RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction.
Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS. Takuma K, et al. Among authors: yan ss, yan s. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20021-6. doi: 10.1073/pnas.0905686106. Epub 2009 Nov 9. Proc Natl Acad Sci U S A. 2009. PMID: 19901339 Free PMC article.
RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.
Fang F, Lue LF, Yan S, Xu H, Luddy JS, Chen D, Walker DG, Stern DM, Yan S, Schmidt AM, Chen JX, Yan SS. Fang F, et al. Among authors: yan ss, yan s. FASEB J. 2010 Apr;24(4):1043-55. doi: 10.1096/fj.09-139634. Epub 2009 Nov 11. FASEB J. 2010. PMID: 19906677 Free PMC article.
We conclude that blockade of microglial RAGE may have a beneficial effect on Abeta-mediated neuronal perturbation relevant to AD pathogenesis.-Fang, F., Lue, L.-F., Yan, S., Xu, H., Luddy, J. S., Chen, D., Walker, D. G., Stern, D. M., Yan, S., S …
We conclude that blockade of microglial RAGE may have a beneficial effect on Abeta-mediated neuronal perturbation relevant to AD pathogenesi …
Synaptic mitochondrial pathology in Alzheimer's disease.
Du H, Guo L, Yan SS. Du H, et al. Antioxid Redox Signal. 2012 Jun 15;16(12):1467-75. doi: 10.1089/ars.2011.4277. Epub 2011 Dec 15. Antioxid Redox Signal. 2012. PMID: 21942330 Free PMC article. Review.
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