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Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.
Drake PM, Albers AE, Baker J, Banas S, Barfield RM, Bhat AS, de Hart GW, Garofalo AW, Holder P, Jones LC, Kudirka R, McFarland J, Zmolek W, Rabuka D. Drake PM, et al. Bioconjug Chem. 2014 Jul 16;25(7):1331-41. doi: 10.1021/bc500189z. Epub 2014 Jun 23. Bioconjug Chem. 2014. PMID: 24924618 Free PMC article.
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