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Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Sun T, et al. Cell. 2011 Mar 4;144(5):703-18. doi: 10.1016/j.cell.2011.02.003. Cell. 2011. PMID: 21376233 Free PMC article.
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.
Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj M. Aceto N, et al. Nat Med. 2012 Mar 4;18(4):529-37. doi: 10.1038/nm.2645. Nat Med. 2012. PMID: 22388088
Hippo inactivation feeds tumor-initiating cells.
Duss S, Britschgi A, Bentires-Alj M. Duss S, et al. Breast Cancer Res. 2012 Aug 7;14(4):318. doi: 10.1186/bcr3190. Breast Cancer Res. 2012. PMID: 22866917 Free PMC article.
108 results