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Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
Goyard D, Kónya B, Chajistamatiou AS, Chrysina ED, Leroy J, Balzarin S, Tournier M, Tousch D, Petit P, Duret C, Maurel P, Somsák L, Docsa T, Gergely P, Praly JP, Azay-Milhau J, Vidal S. Goyard D, et al. Among authors: leroy j. Eur J Med Chem. 2016 Jan 27;108:444-454. doi: 10.1016/j.ejmech.2015.12.004. Epub 2015 Dec 10. Eur J Med Chem. 2016. PMID: 26708111
Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition.
Goyard D, Kónya B, Czifrák K, Larini P, Demontrond F, Leroy J, Balzarin S, Tournier M, Tousch D, Petit P, Duret C, Maurel P, Docsa T, Gergely P, Somsák L, Praly JP, Azay-Milhau J, Vidal S. Goyard D, et al. Among authors: leroy j. Org Biomol Chem. 2020 Feb 7;18(5):931-940. doi: 10.1039/c9ob01190k. Epub 2020 Jan 10. Org Biomol Chem. 2020. PMID: 31922157
Solid-Phase Synthesis of Substrate-Based Dipeptides and Heterocyclic Pseudo-dipeptides as Potential NO Synthase Inhibitors.
Touati-Jallabe Y, Tintillier T, Mauchauffée E, Boucher JL, Leroy J, Ramassamy B, Hamzé A, Mezghenna K, Bouzekrini A, Verna C, Martinez J, Lajoix AD, Hernandez JF. Touati-Jallabe Y, et al. Among authors: leroy j. ChemMedChem. 2020 Mar 18;15(6):517-531. doi: 10.1002/cmdc.201900659. Epub 2020 Feb 27. ChemMedChem. 2020. PMID: 32027778
Reduced production of isoprostanes by peri-pancreatic adipose tissue from Zucker fa/fa rats as a new mechanism for β-cell compensation in insulin resistance and obesity.
Laget J, Vigor C, Nouvel A, Rocher A, Leroy J, Jeanson L, Reversat G, Oger C, Galano JM, Durand T, Péraldi-Roux S, Azay-Milhau J, Lajoix AD. Laget J, et al. Among authors: leroy j. Free Radic Biol Med. 2022 Mar;182:160-170. doi: 10.1016/j.freeradbiomed.2022.02.013. Epub 2022 Feb 25. Free Radic Biol Med. 2022. PMID: 35227851
1,243 results