Ye N - Search Results

1

(6aR)-11-amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease.

Zhao R, Lu W, Fang X, Guo L, Yang Z, Ye N, Zhao J, Liu Z, Jia J, Zheng L, Zhao B, Zhang A, Zhen X. Zhao R, et al. Among authors: ye n. Pharmacol Biochem Behav. 2014 Sep;124:204-10. doi: 10.1016/j.pbb.2014.06.011. Epub 2014 Jun 21. Pharmacol Biochem Behav. 2014. PMID: 24955866

2

Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.

Liu Z, Zhang H, Ye N, Zhang J, Wu Q, Sun P, Li L, Zhen X, Zhang A. Liu Z, et al. Among authors: ye n. J Med Chem. 2010 Feb 11;53(3):1319-28. doi: 10.1021/jm9015763. J Med Chem. 2010. PMID: 20041669

3

Further SAR study on 11-O-substituted aporphine analogues: identification of highly potent dopamine D3 receptor ligands.

Ye N, Wu Q, Zhu L, Zheng L, Gao B, Zhen X, Zhang A. Ye N, et al. Bioorg Med Chem. 2011 Mar 15;19(6):1999-2008. doi: 10.1016/j.bmc.2011.01.053. Epub 2011 Jan 31. Bioorg Med Chem. 2011. PMID: 21334902

4

Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

Zhang H, Ye N, Zhou S, Guo L, Zheng L, Liu Z, Gao B, Zhen X, Zhang A. Zhang H, et al. Among authors: ye n. J Med Chem. 2011 Jul 14;54(13):4324-38. doi: 10.1021/jm200347t. Epub 2011 Jun 2. J Med Chem. 2011. PMID: 21591752

5

Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders.

Ye N, Neumeyer JL, Baldessarini RJ, Zhen X, Zhang A. Ye N, et al. Chem Rev. 2013 May 8;113(5):PR123-78. doi: 10.1021/cr300113a. Epub 2013 Mar 7. Chem Rev. 2013. PMID: 23464812 Review. No abstract available.

6

Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors.

Ye N, Chen CH, Chen T, Song Z, He JX, Huan XJ, Song SS, Liu Q, Chen Y, Ding J, Xu Y, Miao ZH, Zhang A. Ye N, et al. J Med Chem. 2013 Apr 11;56(7):2885-903. doi: 10.1021/jm301825t. Epub 2013 Mar 21. J Med Chem. 2013. PMID: 23473053

7

Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents.

Ye N, Song Z, Zhang A. Ye N, et al. Curr Med Chem. 2014;21(4):437-57. doi: 10.2174/09298673113206660300. Curr Med Chem. 2014. PMID: 24164194 Review.

8

Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials.

Yuan B, Ye N, Song SS, Wang YT, Song Z, Chen HD, Chen CH, Huan XJ, Wang YQ, Su Y, Shen YY, Sun YM, Yang XY, Chen Y, Guo SY, Gan Y, Gao ZW, Chen XY, Ding J, He JX, Zhang A, Miao ZH. Yuan B, et al. Among authors: ye n. Cancer Lett. 2017 Feb 1;386:47-56. doi: 10.1016/j.canlet.2016.11.010. Epub 2016 Nov 12. Cancer Lett. 2017. PMID: 27847302

9

Recent advances in dopaminergic strategies for the treatment of Parkinson's disease.

Mao Q, Qin WZ, Zhang A, Ye N. Mao Q, et al. Among authors: ye n. Acta Pharmacol Sin. 2020 Apr;41(4):471-482. doi: 10.1038/s41401-020-0365-y. Epub 2020 Feb 28. Acta Pharmacol Sin. 2020. PMID: 32112042 Free PMC article. Review.

10

Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.

Ye N, Qin W, Tian S, Xu Q, Wold EA, Zhou J, Zhen XC. Ye N, et al. J Med Chem. 2020 Dec 24;63(24):15187-15217. doi: 10.1021/acs.jmedchem.0c01192. Epub 2020 Oct 28. J Med Chem. 2020. PMID: 33111525 Review.

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